Sugi Predict

Sugi Predict / Compounds / SCHEMBL20634909

SCHEMBL20634909

SCHEMBL20634909

N#Cc1cc(-c2ccc3c(c2N)CCC3)ccn1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NLRP3 Q96P20 2/20 0.45
▸ MYC P01106 1/20 0.40
▸ NOS3 P29474 1/20 0.39
▸ NOS1 P29475 1/20 0.39
▸ NOS2 P35228 1/20 0.39
▸ LRRK2 Q5S007 1/20 0.37
▸ NPY5R Q15761 1/20 0.37
▸ XDH P47989 2/20 0.35
▸ ABCG2 Q9UNQ0 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ HPGD P15428 2/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ USP30 Q70CQ3 2/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ SLC22A12 Q96S37 1/20 0.34
▸ ALOX5AP P20292 1/20 0.34
▸ FEN1 P39748 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22012387 0.84 NLRP3 (0.49) NLRP3MYCLRRK2NPY5RXDH
SCHEMBL24922421 0.82 NLRP3 (0.48) NLRP3MYCLRRK2NPY5RXDH
SCHEMBL21732636 0.82 GRM4 (0.43) NLRP3NOS3NOS1NOS2
SCHEMBL22681147 0.81 NLRP3 (0.43) NLRP3MYCLRRK2NPY5RXDH
SCHEMBL22013483 0.81 NLRP3 (0.43) NLRP3MYCNOS3NOS1NOS2
SCHEMBL23674312 0.81 NPY5R (0.41) NLRP3MYCLRRK2NPY5RXDH
SCHEMBL30112226 0.81 NPY5R (0.41) NLRP3MYCLRRK2NPY5RXDH
SCHEMBL23464705 0.80 NOS3 (0.41) NLRP3NOS3NOS1NOS2XDH
SCHEMBL23063304 0.80 NOS3 (0.41) NOS3NOS1NOS2ALOX5APGSK3B
SCHEMBL21722660 0.80 ADORA2B (0.45) NOS3NOS1NOS2NPY5RDYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators GENENTECH, INC. (US) 2026-05-05 — — US disclosed
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors INFLAZOME LIMITED (IE) 2024-07-09 — — US disclosed
US-11981667-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2024-05-14 — — US disclosed
CN-111132974-B Sulfonamide carboxamide compounds 英夫拉索姆有限公司 2023-11-21 — — CN disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
US-20230037255-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2023-02-02 — — US disclosed
US-20230037255-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2023-02-02 — — US disclosed
US-11530200-B2 Compounds INFLAZOME LIMITED (IE) 2022-12-20 — — US disclosed
US-20210002274-A1 NOVEL COMPOUNDS INFLAZOME LIMITED (IE) 2021-01-07 — — US disclosed
US-20200361895-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2020-11-19 — — US disclosed
US-20200361895-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2020-11-19 — — US disclosed
US-20200291003-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS SYGNATURE DISCOVERY LIMITED (GB) 2020-09-17 — — US disclosed
US-20200291003-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS SYGNATURE DISCOVERY LIMITED (GB) 2020-09-17 — — US disclosed
WO-2020102576-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS INFLAMMASOME RESEARCH, INC. (US) 2020-05-22 — — WO disclosed
CN-111132974-A Novel sulfonamide carboxamide compounds 英夫拉索姆有限公司 2020-05-08 — — CN disclosed
CN-110914256-A Novel sulfonamide carboxamide compounds 英夫拉索姆有限公司 2020-03-24 — — CN disclosed
WO-2019034686-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-02-21 — — WO disclosed
WO-2019008025-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-01-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors NLRP3, NOD1, NLRP1 NLRP3 1/4885MYC 4225/4885NOS3 265/4885
US-20200361895-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 NLRP3 1/4885MYC 4067/4885NOS3 291/4885
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS NLRP3, NLRP1, PYCARD NLRP3 1/4885MYC 3918/4885NOS3 1355/4885
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators NLRP3, NLRP1, PYCARD NLRP3 1/4885MYC 4382/4885NOS3 1579/4885
US-11981667-B2 Sulfonamide carboxamide compounds NLRP3, NOD1, PYCARD NLRP3 1/4885MYC 4116/4885NOS3 85/4885
US-20210002274-A1 NOVEL COMPOUNDS NLRP3, NOD1, NLRP1 NLRP3 1/4885MYC 3240/4885NOS3 181/4885
US-20200291003-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 NLRP3 1/4885MYC 4151/4885NOS3 134/4885
US-20230037255-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 NLRP3 1/4885MYC 4357/4885NOS3 129/4885
US-11530200-B2 Compounds NLRP3, NOD1, NLRP1 NLRP3 1/4885MYC 2959/4885NOS3 53/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.