Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PDE2A | O00408 | 3/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | PTGIR | P43119 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485265 | 0.82 | CNR2 (0.60) | PDE2AMEN1KMT2A | |
| SCHEMBL12125016 | 0.79 | DRD2 (0.57) | — | |
| SCHEMBL6360566 | 0.79 | SIGMAR1 (0.63) | HRH2MEN1KMT2ASIGMAR1 | |
| SCHEMBL8232974 | 0.78 | HRH4 (0.60) | KDM4EHRH2PTGIRHRH3KMT2A | |
| SCHEMBL2291770 | 0.78 | CNR2 (0.61) | — | |
| SCHEMBL2298117 | 0.78 | CNR2 (0.61) | — | |
| SCHEMBL31629226 | 0.77 | CXCR3 (0.44) | KDM4EPDE2AHRH2MEN1KMT2A | |
| SCHEMBL21342345 | 0.77 | DRD2 (0.46) | KDM4EPDE2AHRH2MEN1KMT2A | |
| SCHEMBL30291085 | 0.77 | ALDH1A1 (0.66) | KDM4EHRH2PTGIRHRH3SIGMAR1 | |
| SCHEMBL4592208 | 0.77 | LTA4H (0.50) | KDM4EPDE2AHRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232575-B | Pyrrole [1,2-b ] pyridazine compound or pharmaceutically acceptable salt thereof and application thereof | 中国科学院上海药物研究所 | 2022-01-25 | — | — | CN | disclosed |
| CN-109232575-A | Pyrroles's [1,2-b] pyridazine compound or its officinal salt and their purposes | 中国科学院上海药物研究所 | 2019-01-18 | — | — | CN | disclosed |
| WO-2019011217-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2019-01-17 | — | — | WO | disclosed |