Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.45 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13978041 | 0.79 | PSMD14 (0.48) | PSMD14MMP2TSHRHSP90AA1KCNMA1 | |
| SCHEMBL2053968 | 0.75 | PSMD14 (0.48) | PSMD14METAP2METAP1MMP2TSHR | |
| SCHEMBL31307015 | 0.75 | PSMD14 (0.48) | PSMD14MMP2TSHRHSP90AA1HSP90AB1 | |
| SCHEMBL369216 | 0.75 | PSMD14 (0.48) | PSMD14MMP2TSHRHSP90AA1GRM4 | |
| SCHEMBL19100792 | 0.75 | GRM4 (0.54) | PSMD14METAP2METAP1MMP2TSHR | |
| SCHEMBL569155 | 0.75 | AXL (0.50) | PSMD14MMP2TSHRHSP90AA1KCNMA1 | |
| SCHEMBL3175822 | 0.75 | PSMD14 (0.48) | PSMD14MMP2TSHRHSP90AA1HSP90AB1 | |
| SCHEMBL29364091 | 0.75 | AXL (0.50) | PSMD14MMP2TSHRHSP90AA1KCNMA1 | |
| SCHEMBL22510135 | 0.75 | PSMD14 (0.48) | PSMD14MMP2TSHRHSP90AA1GRM4 | |
| SCHEMBL369215 | 0.75 | PSMD14 (0.48) | PSMD14MMP2TSHRHSP90AA1KCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582709-B1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI SA (FR) | 2018-01-24 | — | — | EP | claimed |
| EP-2001879-B1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE | SANOFI SA (FR) | 2013-08-21 | — | — | EP | claimed |
| US-20130157941-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI (FR) | 2013-06-20 | — | — | US | claimed |
| US-8148395-B2 | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases | SANOFI-AVENTIS (FR) | 2012-04-03 | — | — | US | claimed |
| US-20090054478-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | US | claimed |
| EP-2001879-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE | sanofi-aventis (FR) | 2008-12-17 | — | — | EP | claimed |
| WO-2007110216-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE | SANOFI-AVENTIS (DE) | 2007-10-04 | — | — | WO | claimed |
| US-20190292149-A1 | ARYL SUBSTITUTED INDOLES AND THE USE THEREOF | PURDUE PHARMA LP (US) | 2019-09-26 | — | — | US | disclosed |
| US-10202344-B2 | Aryl substituted indoles and the use thereof | PURDUE PHARMA L.P. (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180022699-A1 | ARYL SUBSTITUTED INDOLES AND THE USE THEREOF | PURDUE PHARMA L.P. | 2018-01-25 | — | — | US | disclosed |
| US-8933024-B2 | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases | SANOFI (FR) | 2015-01-13 | — | — | US | disclosed |
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| EP-2001879-B1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE | SANOFI SA (FR) | 2013-08-21 | — | — | EP | disclosed |
| US-20130157941-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI (FR) | 2013-06-20 | — | — | US | disclosed |
| WO-2012158435-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | ZHOU HAN-JIE (US) | 2012-11-22 | — | — | WO | disclosed |
| US-8148395-B2 | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases | SANOFI-AVENTIS (FR) | 2012-04-03 | — | — | US | disclosed |
| US-20090054478-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | US | disclosed |
| EP-2001879-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE | sanofi-aventis (FR) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110216-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE | SANOFI-AVENTIS (DE) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | USP24, USP36, USP39 | PSMD14 7/4885METAP2 3619/4885METAP1 2779/4885 |
| US-20190292149-A1 | ARYL SUBSTITUTED INDOLES AND THE USE THEREOF | TRPC5, TRPV5, TRPV1 | PSMD14 4552/4885METAP2 2506/4885METAP1 1265/4885 |
| US-20090054478-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | PNLIP, LPL, CEL | PSMD14 3176/4885METAP2 202/4885METAP1 143/4885 |
| US-20180022699-A1 | ARYL SUBSTITUTED INDOLES AND THE USE THEREOF | TRPC5, TRPV5, TRPV1 | PSMD14 4552/4885METAP2 2506/4885METAP1 1265/4885 |
| US-20130157941-A1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | PNLIP, LPL, CEL | PSMD14 3050/4885METAP2 150/4885METAP1 109/4885 |
| US-10202344-B2 | Aryl substituted indoles and the use thereof | TRPC5, TRPV5, TRPV1 | PSMD14 4552/4885METAP2 2506/4885METAP1 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.