Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20693063 | 0.89 | ALOX5 (0.42) | MMP9MMP8 | |
| SCHEMBL20693059 | 0.72 | ALOX5 (0.49) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20693007 | 0.71 | CTSS (0.57) | MMP1MMP2MMP9MMP8CTSS | |
| SCHEMBL3638571 | 0.68 | LDHA (0.46) | MMP1HTTLDHA | |
| SCHEMBL20440150 | 0.68 | CTSS (0.45) | OPRM1OPRD1OPRK1MMP1MMP2 | |
| SCHEMBL6942693 | 0.67 | LDHA (0.54) | TDP1LDHAMEN1KMT2A | |
| SCHEMBL20422635 | 0.67 | ESR1 (0.49) | OPRK1NPC1RAB9AKMT2ACTSS | |
| SCHEMBL3776724 | 0.67 | LDHA (0.54) | TDP1LDHAMEN1KMT2A | |
| SCHEMBL20422634 | 0.67 | ESR1 (0.49) | OPRK1NPC1RAB9AKMT2ACTSS | |
| SCHEMBL3777215 | 0.66 | LDHA (0.46) | HTTALDH1A1LDHASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019018890-A1 | NOVEL SPIROCYCLIC COMPOUNDS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2019-01-31 | — | — | WO | disclosed |