Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20693060 | 0.89 | OPRM1 (0.39) | MMP9MMP8 | |
| SCHEMBL20693059 | 0.85 | ALOX5 (0.49) | ALOX5MAOBLTA4HLTB4RLTB4R2 | |
| SCHEMBL20693005 | 0.74 | BCL2 (0.59) | YAP1BCL2ACEPTPN1 | |
| SCHEMBL20693062 | 0.72 | MMP9 (0.55) | ALOX5LTA4HMMP9MMP8FFAR1 | |
| SCHEMBL6474783 | 0.71 | ITGB3 (0.55) | ALOX5MAOBLTA4HYAP1FFAR1 | |
| SCHEMBL16634946 | 0.71 | ITGB3 (0.55) | ALOX5MAOBLTA4HYAP1FFAR1 | |
| SCHEMBL29397771 | 0.71 | ITGB3 (0.55) | ALOX5MAOBLTA4HYAP1FFAR1 | |
| SCHEMBL289190 | 0.71 | PPARG (0.48) | ALOX5MAOBLTA4HMMP9MMP8 | |
| SCHEMBL18918265 | 0.70 | LTA4H (0.52) | ALOX5MAOBLTA4HLTB4RLTB4R2 | |
| SCHEMBL20693061 | 0.69 | MAOB (0.48) | ALOX5MAOBLTA4HMMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019018890-A1 | NOVEL SPIROCYCLIC COMPOUNDS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2019-01-31 | — | — | WO | disclosed |