Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705751 | 0.89 | HTR6 (0.36) | ACHECDC25ACDC25BCDC25CPDE4A | |
| SCHEMBL1779822 | 0.67 | TSHR (0.41) | ACHETSHRCYP3A4TOP1PDE3A | |
| SCHEMBL24194104 | 0.66 | PIM1 (0.43) | TSHRCYP3A4PIM1TOP1LMNA | |
| SCHEMBL27854879 | 0.66 | ACHE (0.44) | ACHETSHRCYP3A4PDE4AABCC4 | |
| SCHEMBL30574283 | 0.65 | TOP1 (0.66) | CYP3A4CDC25BTOP1LMNAALDH1A1 | |
| SCHEMBL24194098 | 0.65 | TOP1 (0.66) | CYP3A4CDC25BTOP1LMNAALDH1A1 | |
| SCHEMBL15119582 | 0.61 | ACHE (0.47) | ACHETSHRCYP3A4CDC25BADORA3 | |
| SCHEMBL9839597 | 0.61 | TSHR (0.47) | ACHETSHRCYP3A4LMNAALDH1A1 | |
| SCHEMBL11491934 | 0.60 | TSHR (0.58) | ACHETSHRCYP3A4PDE4ALMNA | |
| SCHEMBL19582577 | 0.59 | ALDH1A1 (0.45) | ACHETSHRCYP3A4PDE4APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10197557-B2 | Small molecules for endothelial cell activation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10197557-B2 | Small molecules for endothelial cell activation | LIPG, VCAM1, SELE | ACHE 4324/4885TSHR 4000/4885CYP3A4 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.