Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.31 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
| ▸ | ADH7 | P40394 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25488050 | 0.84 | LMNA (0.36) | ALDH1A1MAPTPOLBAKT1SMN1; SMN2 | |
| SCHEMBL19501167 | 0.79 | KDM4E (0.40) | POLBAKT1SMN1; SMN2LMNA | |
| SCHEMBL21501800 | 0.73 | POLB (0.37) | ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL19597509 | 0.70 | GPR84 (0.36) | SMN1; SMN2GPR84OPRM1SPHK1LMNA | |
| SCHEMBL21115896 | 0.69 | GLS (0.33) | ALDH1A1MAPTLMNA | |
| SCHEMBL23219755 | 0.69 | GPR84 (0.38) | GPR84OPRM1 | |
| SCHEMBL24608829 | 0.69 | GPR84 (0.38) | GPR84OPRM1 | |
| SCHEMBL19370495 | 0.68 | NPC1 (0.41) | GPR84NPC1RAB9A | |
| SCHEMBL20630571 | 0.66 | ALDH1A1 (0.37) | ALDH1A1MAPTPOLBSMN1; SMN2TSHR | |
| SCHEMBL20828428 | 0.66 | KMT2A (0.46) | ALDH1A1POLBSMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544155-B2 | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190040076-A1 | Spirocyclic Quinolizine Derivatives Useful as HIV Integrase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544155-B2 | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors | NQO2, SIRT5, CCR5 | ALDH1A1 704/4885MAPT 3508/4885POLB 515/4885 |
| US-20190040076-A1 | Spirocyclic Quinolizine Derivatives Useful as HIV Integrase Inhibitors | NQO2, SIRT5, CCR5 | ALDH1A1 704/4885MAPT 3508/4885POLB 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.