Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | GALR3 | O60755 | 1/20 | 0.63 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.59 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170123 | 0.89 | SMN1; SMN2 (0.74) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL22726434 | 0.87 | ALDH1A1 (0.62) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL27898218 | 0.86 | ALDH1A1 (0.76) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL27915822 | 0.86 | ALDH1A1 (0.76) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL20715444 | 0.82 | HTT (0.72) | NOD2KDM4ENOD1SMN1; SMN2KMT2A | |
| SCHEMBL1169930 | 0.81 | SMN1; SMN2 (0.66) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL20715331 | 0.81 | DRD2 (0.69) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL3201350 | 0.80 | KMT2A (0.57) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL8734474 | 0.80 | NOD1 (0.70) | NOD2ALDH1A1KDM4ENOD1DRD2 | |
| SCHEMBL20715311 | 0.79 | SMN1; SMN2 (0.69) | NOD2ALDH1A1KDM4ENOD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200377505-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2020-12-03 | — | — | US | disclosed |
| WO-2019028308-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377505-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | AZI2, ATP6V1B1, GLS | NOD2 4151/4885ALDH1A1 54/4885KDM4E 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.