Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.47 |
| ▸ | PGR | P06401 | 8/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.47 |
| ▸ | AR | P10275 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2072627 | 0.83 | SLC6A2 (0.60) | SLC6A4CYP2D6SLC6A2KCNH2NR3C1 | |
| SCHEMBL12397686 | 0.81 | NR3C1 (0.47) | SLC6A4CYP2D6SLC6A2KCNH2NR3C1 | |
| SCHEMBL2071176 | 0.81 | SLC6A4 (0.64) | SLC6A4CYP2D6SLC6A2KCNH2HTR2A | |
| SCHEMBL2075044 | 0.81 | SLC6A4 (0.67) | SLC6A4CYP2D6SLC6A2KCNH2HTR2A | |
| SCHEMBL2074712 | 0.81 | SLC6A4 (0.67) | SLC6A4CYP2D6SLC6A2KCNH2HTR2A | |
| SCHEMBL12397693 | 0.80 | NR3C1 (0.45) | NR3C1PGRNR3C2ARPLA2G7 | |
| SCHEMBL12933744 | 0.80 | SLC6A4 (0.66) | SLC6A4CYP2D6SLC6A2KCNH2HTR2A | |
| SCHEMBL2074877 | 0.80 | SLC6A4 (0.66) | SLC6A4CYP2D6SLC6A2KCNH2HTR2A | |
| SCHEMBL12397692 | 0.79 | NR3C1 (0.42) | SLC6A4CYP2D6SLC6A2KCNH2NR3C1 | |
| SCHEMBL12397541 | 0.79 | NR3C1 (0.43) | SLC6A4CYP2D6SLC6A2KCNH2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| EP-1756054-B1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-03-31 | — | — | EP | disclosed |
| US-20060025467-A1 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025467-A1 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | TPH1, HTR1A, HTR3A | SLC6A4 14/4885CYP2D6 67/4885SLC6A2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.