Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.80 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | XDH | P47989 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tectorigenin SCHEMBL351641 | 0.89 | EGFR (1.00) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| Tectorigenin SCHEMBL29353966 | 0.89 | EGFR (1.00) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| Glycitein SCHEMBL869704 | 0.82 | HDAC6 (0.83) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| Genistein SCHEMBL554356 | 0.82 | SMN1; SMN2 (0.79) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| SCHEMBL7760758 | 0.82 | EGFR (0.76) | EGFRALDH2ALDH1A1CYP3A4MAPT | |
| Irisolidone SCHEMBL30997344 | 0.81 | EGFR (0.84) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| Irisolidone SCHEMBL1974327 | 0.81 | EGFR (0.84) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| Isoflavone SCHEMBL3066716 | 0.80 | ALOX12 (0.80) | EGFRALDH2HDAC6ALDH1A1CYP3A4 | |
| Tectoridin SCHEMBL18586434 | 0.80 | ALDH1A1 (0.66) | EGFRALDH2ALDH1A1CYP3A4MAPT | |
| Irilin D SCHEMBL571722 | 0.79 | EGFR (0.80) | EGFRALDH2ALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107216243-B | Chalcone analogue and preparation method and application thereof | 四川省中医药科学院 | 2020-08-28 | — | — | CN | disclosed |
| US-7902253-B2 | Isoflavone derivatives of tectorigenin, the preparation thereof and the antiviral medicine containing the same as an effective constituent | CHENGDU DIKANG PHARMACEUTICAL INSTITUTE (CN) | 2011-03-08 | — | — | US | disclosed |
| EP-1630160-B1 | THE ISOFLAVONE DERIVATIVES OF TECTORIDIN, THE PREPARATION THEREOF AND THE ANTI-VIRUS MEDICINES CONTAINING THE SAME AS THE EFFECTIVE CONSTITUENTS | CHENGDU DIKANG PHARMACEUTICAL (CN) | 2009-04-08 | — | — | EP | disclosed |
| US-20070123566-A1 | Isoflavone derivatives of tectoridin, the preparation thereof and the anti-virus medicines containing the same as an effective constituents | CHENGDU DIKANG PHARMACEUTICAL INSTITUTE (CN) | 2007-05-31 | — | — | US | disclosed |
| EP-1630160-A1 | THE ISOFLAVONE DERIVATIVES OF TECTORIDIN, THE PREPARATION THEREOF AND THE ANTI-VIRUS MEDICINES CONTAINING THE SAME AS THE EFFECTIVE CONSTITUENTS | Chengdu Dikang Pharmaceutical Institute (CN) | 2006-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123566-A1 | Isoflavone derivatives of tectoridin, the preparation thereof and the anti-virus medicines containing the same as an effective constituents | CCNE2, TEC, NFE2 | EGFR 1446/4885ALDH2 4491/4885HDAC6 3015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.