Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8611414 | 0.87 | DHFR (0.39) | KMT2ADHFR | |
| SCHEMBL10931233 | 0.83 | NFE2L2 (0.39) | HTR7TAAR1NPC1RAB9AKMT2A | |
| SCHEMBL29955310 | 0.82 | HTR7 (0.44) | HTR7TAAR1NPC1RAB9AKMT2A | |
| SCHEMBL5543014 | 0.79 | HTR7 (0.43) | HTR7TAAR1NPC1RAB9AKMT2A | |
| SCHEMBL8613693 | 0.79 | ALDH1A1 (0.55) | HTR7ACHE | |
| SCHEMBL21020669 | 0.79 | TP53 (0.46) | NPC1RAB9ASLC6A2SLC6A4DHFR | |
| SCHEMBL7223872 | 0.79 | PYCR1 (0.42) | HTR7TAAR1KMT2ADHFRRIPK1 | |
| SCHEMBL21021269 | 0.77 | APP (0.44) | HTR7TAAR1SLC6A2SLC6A4DHFR | |
| SCHEMBL9809614 | 0.77 | HTR7 (0.44) | HTR7TAAR1NPC1RAB9AKMT2A | |
| SCHEMBL22968467 | 0.77 | HTR7 (0.38) | HTR7TAAR1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3444237-B1 | IRIDINESULFONAMIDE COMPOUND AND USE METHOD THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2020-10-28 | — | — | EP | disclosed |
| EP-3444237-A1 | IRIDINESULFONAMIDE COMPOUND AND USE METHOD THEREOF | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-02-20 | — | — | EP | disclosed |