Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753852 | 0.82 | POLB (0.45) | POLBL3MBTL1ALDH1A1ABL1BCR | |
| SCHEMBL18753710 | 0.82 | CPS1 (0.46) | POLBLMNATSHRGAA | |
| SCHEMBL18753335 | 0.80 | LMNA (0.47) | POLBLMNATSHR | |
| SCHEMBL20750674 | 0.76 | EPHX2 (0.49) | POLBSMN1; SMN2CA12CA1CA2 | |
| SCHEMBL18753377 | 0.75 | HPGD (0.61) | POLBNAMPTSMN1; SMN2L3MBTL1CA12 | |
| SCHEMBL8257601 | 0.75 | HPGD (0.54) | POLBL3MBTL1ALDH1A1LMNATSHR | |
| SCHEMBL18753814 | 0.74 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2L3MBTL1ALDH1A1LMNA | |
| SCHEMBL20750677 | 0.74 | CHRNA4 (0.44) | NAMPTSMN1; SMN2L3MBTL1ALDH1A1LMNA | |
| SCHEMBL20192480 | 0.73 | PKM (0.47) | POLBL3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL20750408 | 0.73 | ALDH1A1 (0.43) | POLBNAMPTSMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704720-B1 | PYRUVATE KINASE R ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS INC (US) | 2019-08-07 | — | — | EP | disclosed |
| EP-2658543-B1 | PYRUVATE KINASE M2 (PKM2) ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |