Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207490 | 0.84 | AHR (0.42) | AHRCMA1ALDH1A1PSMB8HPGD | |
| SCHEMBL207189 | 0.76 | KIF11 (0.35) | ALDH1A1HPGDNR4A2POLBNOS1 | |
| SCHEMBL207535 | 0.76 | AHR (0.42) | AHRALDH1A1NR4A2GPR84NOS1 | |
| SCHEMBL17423817 | 0.75 | — | — | |
| SCHEMBL6357105 | 0.71 | ALDH1A1 (0.37) | ALDH1A1TSHRALOX15HSD17B10KDM4E | |
| SCHEMBL1968319 | 0.71 | MEN1 (0.47) | ALDH1A1PSMB8HPGDTSHRPOLB | |
| SCHEMBL4502393 | 0.70 | KDM4E (0.49) | ALDH1A1HPGDTSHRPOLBHSD17B10 | |
| SCHEMBL649172 | 0.69 | CYP3A4 (0.49) | ALDH1A1PSMB8TSHRPOLBALOX15 | |
| SCHEMBL152187 | 0.68 | CSNK2A1 (0.44) | AHR | |
| SCHEMBL10355483 | 0.68 | TSHR (0.39) | ALDH1A1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024052431-A1 | PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS AND USE THEREOF | 3B PHARMACEUTICALS GMBH (DE) | 2024-03-14 | — | — | WO | claimed |
| US-11369584-B2 | Andrographolide derivatives and method of using the same for treatment or prevention of fibrosis | ZHENGZHOU UNIVERSITY (CN) | 2022-06-28 | — | — | US | claimed |
| CN-109824654-B | 15-methylene-14-deoxy-11, 12-dehydroandrographolide derivatives and pharmaceutical application thereof | 郑州大学 | 2022-04-08 | — | — | CN | claimed |
| CN-113152091-A | Polysaccharide-based hydrogel-based fabric for visually detecting escherichia coli and pH response and preparation method thereof | 东华大学 | 2021-07-23 | — | — | CN | claimed |
| CN-111533767-A | Tetradentate phosphine ligand and preparation method thereof, hydroformylation catalyst and reaction method, and preparation method of 1, 3-propylene glycol | 卢海元 | 2020-08-14 | — | — | CN | claimed |
| CN-111170954-A | Phenalenone compounds and application thereof | 大连理工大学 | 2020-05-19 | — | — | CN | claimed |
| EP-3608313-A1 | 15-IDENE-14-DEOXY-11,12-DEHYDROANDROGRAPHOLIDE DERIVATIVE AND APPLICATION THEREOF IN PREPARING ANTI-FIBROSIS DRUGS | Zhengzhou University (CN) | 2020-02-12 | — | — | EP | claimed |
| US-20200030280-A1 | ANDROGRAPHOLIDE DERIVATIVES AND METHOD OF USING THE SAME FOR TREATMENT OR PREVENTION OF FIBROSIS | ZHENGZHOU UNIVERSITY (CN) | 2020-01-30 | — | — | US | claimed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | claimed |
| EP-2836839-A1 | METHOD AND KIT FOR DETECTING THE LH PREOVULATORY SURGE | Repropharm (FR) | 2015-02-18 | — | — | EP | claimed |
| US-20030130335-A1 | Bis-Heteroaryl alkanes as therapeutic agents | TRANSTECH PHARMA, LLC | 2003-07-10 | — | — | US | claimed |
| WO-2003035896-A2 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | BURTON MICHAEL (GB) | 2003-05-01 | — | — | WO | claimed |
| WO-2003032982-A1 | BIS-HETEROARYL ALKANES AS THERAPEUTIC AGENTS | TRANSTECH PHARMA, INC. (US) | 2003-04-24 | — | — | WO | claimed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |
| US-6333339-B1 | CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS | MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) | 2001-12-25 | — | — | US | claimed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | claimed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | claimed |
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | claimed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | claimed |
| US-5210022-A | Substrates sensitive to beta-galactosidase and beta-glucuronidase, quantitative analysis | RCR SCIENTIFIC, INC. (US) | 1993-05-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030280-A1 | ANDROGRAPHOLIDE DERIVATIVES AND METHOD OF USING THE SAME FOR TREATMENT OR PREVENTION OF FIBROSIS | MMP1, CYP27A1, PYGL | AHR 2725/4885CMA1 345/4885ALDH1A1 356/4885 |
| US-20030130335-A1 | Bis-Heteroaryl alkanes as therapeutic agents | PTPRG, PTPRS, PTPRJ | AHR 90/4885CMA1 582/4885ALDH1A1 1952/4885 |
| US-11369584-B2 | Andrographolide derivatives and method of using the same for treatment or prevention of fibrosis | MMP1, CYP27A1, PYGL | AHR 2725/4885CMA1 345/4885ALDH1A1 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.