Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 2/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20786519 | 0.91 | CXCR3 (0.34) | KDM4EALDH1A1MAPTFAAHMEN1 | |
| SCHEMBL20786621 | 0.86 | CTSS (0.42) | — | |
| SCHEMBL20768310 | 0.86 | CTSS (0.42) | — | |
| Hydrochloric Acid SCHEMBL20768337 | 0.85 | CTSS (0.42) | — | |
| Hydrochloric Acid SCHEMBL20768338 | 0.85 | CTSS (0.42) | — | |
| SCHEMBL20786350 | 0.82 | ALDH1A1 (0.38) | KDM4EALDH1A1MAPTFAAHSSTR5 | |
| SCHEMBL20768320 | 0.81 | KDM1A (0.32) | — | |
| SCHEMBL20768330 | 0.80 | CTSS (0.44) | — | |
| SCHEMBL20786714 | 0.78 | CTSS (0.42) | — | |
| SCHEMBL20786461 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1MAPTFAAHSSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574422-B | Phenyl difluoromethyl substituted prolinamide compounds | 安斯泰来制药株式会社 | 2023-09-08 | — | — | CN | disclosed |
| CN-111574422-A | Phenyl difluoromethyl substituted prolyl compounds | 安斯泰来制药株式会社 | 2020-08-25 | — | — | CN | disclosed |
| CN-110248925-B | Phenyl difluoromethyl substituted prolyl compounds | 安斯泰来制药株式会社 | 2020-07-17 | — | — | CN | disclosed |
| CN-110248925-A | Phenyl difluoromethyl substituted prolyl compounds | 安斯泰来制药株式会社 | 2019-09-17 | — | — | CN | disclosed |
| US-20190248738-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-08-15 | — | — | US | disclosed |
| US-20190248738-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-08-15 | — | — | US | disclosed |
| US-10322997-B2 | Phenyldifluoromethyl-substituted prolinamide compound | ASTELLAS PHARMA INC. (JP) | 2019-06-18 | — | — | US | disclosed |
| US-10322997-B2 | Phenyldifluoromethyl-substituted prolinamide compound | ASTELLAS PHARMA INC. (JP) | 2019-06-18 | — | — | US | disclosed |
| US-20190071398-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-03-07 | — | — | US | disclosed |
| US-20190071398-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248738-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | CTSV, CTSS, CTSF | KDM4E 125/4885ALDH1A1 1534/4885MAPT 3597/4885 |
| US-10322997-B2 | Phenyldifluoromethyl-substituted prolinamide compound | CTSV, CTSS, CTSF | KDM4E 125/4885ALDH1A1 1534/4885MAPT 3597/4885 |
| US-20190071398-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | CTSS, CTSV, CTSF | KDM4E 926/4885ALDH1A1 2654/4885MAPT 4105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.