Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.68 |
| ▸ | CCND1 | P24385 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30342074 | 1.00 | CDK4 (0.68) | CDK4CCND1KMT2ALMNAHTR2A | |
| Pyrrolidine SCHEMBL3186238 | 0.86 | CDK4 (0.52) | CDK4CCND1KMT2ALMNAHTR2A | |
| Piperidine SCHEMBL3175683 | 0.84 | CDK4 (0.50) | CDK4CCND1KMT2ALMNAHTR2A | |
| SCHEMBL734246 | 0.83 | CDK4 (0.76) | CDK4CCND1KMT2ALMNAHTR2A | |
| SCHEMBL30063707 | 0.83 | CDK4 (0.76) | CDK4CCND1KMT2ALMNAHTR2A | |
| SCHEMBL11366447 | 0.81 | CDK4 (1.00) | CDK4CCND1KMT2ALMNAHTR2A | |
| SCHEMBL30701168 | 0.79 | CDK4 (0.78) | CDK4CCND1KMT2ALMNAHTR2A | |
| SCHEMBL4992403 | 0.79 | CDK4 (0.78) | CDK4CCND1KMT2ALMNAHTR2A | |
| SCHEMBL945970 | 0.79 | CDK4 (0.71) | CDK4CCND1KMT2ALMNAHTR2A | |
| Alcohol SCHEMBL734139 | 0.78 | CDK4 (0.68) | CDK4CCND1KMT2ALMNAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118696035-A | Spiropiperidyl derivatives as complement factor B inhibitors and their use | 诺华股份有限公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-109689111-B | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | 基因泰克公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-110526903-A | Bisindole maleimide derivative and its preparation method and application | OCEAN UNIV CHINA | 2019-12-03 | — | — | CN | disclosed |
| CN-110218206-A | Bisindole maleimide derivative and its preparation method and application | 中国海洋大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-106083830-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2019-07-12 | — | — | CN | disclosed |
| CN-106146475-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2019-05-17 | — | — | CN | disclosed |
| US-10174005-B2 | Fused pyrimidines as inhibitors of p97 complex | CLEAVE BIOSCIENCES, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-9969685-B2 | Enantioselective synthesis of pyrroloindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-15 | — | — | US | disclosed |
| WO-2018064094-A1 | ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-05 | — | — | WO | disclosed |
| US-20180086701-A1 | ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-29 | — | — | US | disclosed |
| WO-2007021897-A1 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20070037801-A1 | {1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl}(2,2,3,3-tetramethylcyclopropyl)methanone toluenesufonic acid salt; selectively target cannaboid B2 receptors; analgesics for both nociceptive and neuropathic pain; side effect reduction; immunology modulators; antiinflammatory agents; neuroprotectants | ABBVIE INC. | 2007-02-15 | — | — | US | disclosed |
| WO-2006069196-A1 | 3-CYCLOALKYLCARBONYL INDOLES AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2006-06-29 | — | — | WO | disclosed |
| US-5646098-A | Carbonyl containing compounds and their derivatives as multi-functional fuel and lube additives | EXXON CHEMICAL PATENTS INC (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996026207-A1 | THIAZOLIDINE AND OXAZOLIDINE INDOLES WITH HYPOCLYCEMIC ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1996-08-29 | — | — | WO | disclosed |
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |
| US-4118395-A | Method for the production of indolyl lactones | FRANTSITS WERNER J | 1978-10-03 | — | — | US | disclosed |
| US-3996241-A | 2-Hydroxymethyl indole compounds and blood sugar lowering compositions | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174005-B2 | Fused pyrimidines as inhibitors of p97 complex | WDR77, POP1, PSMG3 | CDK4 1733/4885CCND1 2265/4885KMT2A 3453/4885 |
| US-20070037801-A1 | {1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl}(2,2,3,3-tetramethylcyclopropyl)methanone toluenesufonic acid salt; selectively target cannaboid B2 receptors; analgesics for both nociceptive and neuropathic pain; side effect reduction; immunology modulators; antiinflammatory agents; neuroprotectants | CNR2, CNR1, TRPV1 | CDK4 1597/4885CCND1 3101/4885KMT2A 3322/4885 |
| US-20180086701-A1 | ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS | PCNA, POLR2E, POLL | CDK4 706/4885CCND1 203/4885KMT2A 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.