Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769668 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNAPLA2G4AKDM4ETBXAS1 | |
| SCHEMBL20788555 | 0.79 | ALDH1A1 (0.46) | ALDH1A1LMNAPLA2G4AAKR1C3AKR1C2 | |
| SCHEMBL20769657 | 0.79 | PLA2G4A (0.53) | ALDH1A1LMNAPLA2G4AAKR1C3AKR1C2 | |
| SCHEMBL20769670 | 0.78 | KCNH2 (0.59) | PLA2G4AAKR1C3AKR1C2AKR1C4PTGS1 | |
| SCHEMBL20769663 | 0.77 | ALDH1A1 (0.56) | ALDH1A1LMNAPLA2G4AAKR1C3AKR1C2 | |
| SCHEMBL20788566 | 0.76 | MAT2A (0.43) | ALDH1A1LMNAHTR7KDM4EMAPT | |
| SCHEMBL20769700 | 0.74 | LMNA (0.75) | ALDH1A1LMNAPLA2G4APPARGPPARD | |
| SCHEMBL3130548 | 0.73 | PLA2G4A (0.72) | PLA2G4A | |
| SCHEMBL20769675 | 0.73 | AKR1C3 (0.72) | ALDH1A1LMNAAKR1C3AKR1C2HTR7 | |
| SCHEMBL6242130 | 0.72 | KMT2A (0.52) | ALDH1A1LMNAAKR1C3AKR1C2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |