Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SCN2B | O60939 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769670 | 0.89 | KCNH2 (0.59) | PLA2G4AKCNH2AKR1C3AKR1C2KEAP1 | |
| SCHEMBL20788555 | 0.82 | ALDH1A1 (0.46) | PLA2G4AALDH1A1LMNAKCNH2AKR1C3 | |
| SCHEMBL20769652 | 0.79 | ALDH1A1 (0.44) | PLA2G4AALDH1A1LMNAKCNH2AKR1C3 | |
| SCHEMBL20769743 | 0.78 | LMNA (0.82) | PLA2G4AALDH1A1LMNA | |
| SCHEMBL8174649 | 0.78 | ALDH1A1 (0.57) | PLA2G4AALDH1A1LMNA | |
| SCHEMBL6242130 | 0.77 | KMT2A (0.52) | ALDH1A1LMNAAKR1C3AKR1C2HPGD | |
| SCHEMBL10946754 | 0.76 | AKR1C3 (0.69) | PLA2G4AALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL20769700 | 0.76 | LMNA (0.75) | PLA2G4AALDH1A1LMNA | |
| SCHEMBL3116983 | 0.75 | PLA2G4A (0.84) | PLA2G4A | |
| SCHEMBL8454150 | 0.75 | HTR7 (0.56) | PLA2G4AALDH1A1LMNASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |