Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ICMT | O60725 | 5/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769651 | 0.82 | ALDH1A1 (0.60) | SLC22A12ALDH1A1LMNAICMTPPARD | |
| SCHEMBL20769700 | 0.81 | LMNA (0.75) | ALDH1A1LMNAICMTPPARDMEN1 | |
| SCHEMBL20769743 | 0.80 | LMNA (0.82) | ALDH1A1LMNAICMTPPARDMEN1 | |
| SCHEMBL20769672 | 0.80 | AKR1C3 (0.56) | ALDH1A1LMNAICMTPPARDMEN1 | |
| SCHEMBL20769719 | 0.80 | ALDH1A1 (0.65) | ALDH1A1LMNAICMTPPARDSMN1; SMN2 | |
| SCHEMBL20769698 | 0.77 | TBXAS1 (0.48) | ALDH1A1LMNAICMTPPARDPPARG | |
| SCHEMBL20769663 | 0.77 | ALDH1A1 (0.56) | ALDH1A1LMNAICMTPPARDPTGDR2 | |
| SCHEMBL20789122 | 0.76 | HTT (0.50) | SLC22A12ALDH1A1LMNAMEN1HTT | |
| SCHEMBL20769731 | 0.76 | ALDH1A1 (0.58) | SLC22A12ALDH1A1LMNAICMTPPARD | |
| SCHEMBL20769685 | 0.75 | ALDH1A1 (0.60) | ALDH1A1LMNAICMTPPARDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |