Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | YES1 | P07947 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | BMP4 | P12644 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.52 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.52 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836681 | 0.74 | PTGS2 (0.70) | KDRSRCPTGS2 | |
| SCHEMBL8836442 | 0.74 | PTGS2 (0.70) | KDRSRCPTGS2 | |
| SCHEMBL18837471 | 0.73 | LTA4H (0.84) | LTA4HHRH3PTGS2 | |
| SCHEMBL17128931 | 0.73 | PTGS2 (0.44) | JAK2JAK3SRCPTGS2CYP1A2 | |
| SCHEMBL12050716 | 0.72 | HRH3 (0.82) | LTA4HHRH3 | |
| SCHEMBL25059331 | 0.71 | LTA4H (0.87) | LTA4HHRH3PTGS2KDM4E | |
| SCHEMBL27211392 | 0.71 | TGFBR1 (0.60) | JAK2JAK3FLT1KDRBMPR1B | |
| SCHEMBL8836701 | 0.71 | PTGS2 (0.53) | LCKESR1ESR2PTGS2MAPT | |
| SCHEMBL2635534 | 0.71 | JAK2 (1.00) | JAK2JAK3PTK2 | |
| SCHEMBL21234366 | 0.69 | LTA4H (0.60) | FLT1KDRBMPR1BPRKAB2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240052418-A1 | METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-02-15 | — | — | US | disclosed |
| US-11814681-B2 | Method for predicting a subjects response to SLC modulator therapy | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-11-14 | — | — | US | disclosed |
| EP-4110465-A1 | MOLECULAR BIOMARKERS AND TARGETS FOR FUCHS' ENDOTHELIAL CORNEAL DYSTROPHY AND GLAUCOMA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-01-04 | — | — | EP | disclosed |
| US-20210348234-A1 | MOLECULAR BIOMARKERS AND TARGETS FOR FUCHES' ENDOTHELIAL CORNEAL DYSTROPHY AND GLAUCOMA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-11-11 | — | — | US | disclosed |
| US-20210254158-A1 | METHOD FOR PREDICTING A SUBJECTS RESPONSE TO SLC MODULATOR THERAPY | RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. | 2021-08-19 | — | — | US | disclosed |
| WO-2019046303-A1 | A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-07 | — | — | WO | disclosed |