SCHEMBL207905

SCHEMBL207905

Clc1ccc2n[c]oc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.44
PSMB8 P28062 2/20 0.41
PSMB5 P28074 1/20 0.41
F7 P08709 1/20 0.38
F3 P13726 1/20 0.38
DYRK1A Q13627 1/20 0.38
MAPT P10636 2/20 0.36
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
THRB P10828 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36
POLB P06746 1/20 0.36
GAA P10253 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL207390 0.83 LMNA (0.44) PIK3CGPSMB8PSMB5F7F3
SCHEMBL209566 0.75 KDM4E (0.34) MAPTLMNAMAPK1ALDH1A1KDM4E
SCHEMBL939151 0.75 KDM4E (0.43) MAPTCYP1A2ALDH1A1HPGDSMN1; SMN2
SCHEMBL4150810 0.75 KDM4E (0.42) PSMB8DYRK1AMAPTLMNAALDH1A1
SCHEMBL207175 0.75 BACE1 (0.34) CYP1A2ALDH1A1AHRPTPN1MEN1
SCHEMBL7193461 0.75 ALDH1A1 (0.42) F7F3DYRK1AMAPTLMNA
SCHEMBL5331382 0.74 AHR (0.36) DYRK1AMAPTALDH1A1HPGDKDM4E
SCHEMBL533256 0.71 ALDH1A1 (0.43) MAPTLMNACYP1A2THRBMAPK1
SCHEMBL208752 0.71 MAP3K14 (0.33)
SCHEMBL11784333 0.71 SCN10A (0.36) MAPTALOX15ALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118164921-A Propyl phenoxypropionate compound, preparation method thereof and application thereof as herbicide 山东德瑞克化工科技有限公司 2024-06-11 CN claimed
US-20230158025-A1 GALACTOKINASE INHIBITORS NATIONAL INSTITUTES OF HEALTH 2023-05-25 US claimed
WO-2021216812-A1 GALACTOKINASE INHIBITORS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2021-10-28 WO claimed
EP-3321262-B1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2021-01-13 EP claimed
US-10077261-B2 Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer JANSSEN PHARMACEUTICA NV (BE) 2018-09-18 US claimed
EP-3321262-A1 SERINE/THREONINE KINASE INHIBITORS Array Biopharma, Inc. (US) 2018-05-16 EP claimed
US-20180127393-A1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2018-05-10 US claimed
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 EP claimed
EP-2892892-B1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA NV (BE) 2017-05-31 EP claimed
EP-2387569-B1 HERBCIDES SYNGENTA LTD (GB) 2016-06-15 EP claimed
WO-2012085857-A1 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES ACTELION PHARMACEUTICALS LTD (CH) 2012-06-28 WO claimed
US-20100279871-A1 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME KYUNG NONG CORPORATION (KR) 2010-11-04 US claimed
EP-2183213-A2 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME Kyung Nong Corporation (KR) 2010-05-12 EP claimed
WO-2009005297-A2 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME KYUNG NONG CORPORATION (KR) 2009-01-08 WO claimed
US-20030216571-A1 Antiallergens; antiinflammatory agents UBE INDUSTRIES, LTD. (JP) 2003-11-20 US claimed
EP-1254897-A1 TRICYCLIC COMPOUNDS Ube Industries, Ltd. (JP) 2002-11-06 EP claimed
EP-0148119-B1 AMIDES OF 2-PHENOXYPROPIONIC ACID CIBA-GEIGY AG (CH) 1989-05-03 EP claimed
EP-0296319-A1 Herbicidal agents based on heteroarylphenoxycarboxylid-acid derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1988-12-28 EP claimed
EP-0148119-A2 Amides of 2-phenoxypropionic acid CIBA-GEIGY AG (CH) 1985-07-10 EP claimed
EP-0144796-A2 Herbicidal agents HOECHST AKTIENGESELLSCHAFT (DE) 1985-06-19 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100279871-A1 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME AADAC, DDT, NOTUM PIK3CG 2751/4885PSMB8 3671/4885PSMB5 2658/4885
US-10077261-B2 Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer FASN, PLIN1, FABP1 PIK3CG 2013/4885PSMB8 4458/4885PSMB5 3444/4885
US-20230158025-A1 GALACTOKINASE INHIBITORS GALK1, GCK, GCKR PIK3CG 1210/4885PSMB8 3700/4885PSMB5 4591/4885
US-20180127393-A1 SERINE/THREONINE KINASE INHIBITORS MAP3K1, MAP3K11, TTBK1 PIK3CG 764/4885PSMB8 2154/4885PSMB5 3348/4885
US-20030216571-A1 Antiallergens; antiinflammatory agents CYSLTR2, CYSLTR1, LTC4S PIK3CG 4653/4885PSMB8 1032/4885PSMB5 362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.