SCHEMBL5331382

SCHEMBL5331382

Clc1cc2n[c]oc2cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.36
MAPK13 O15264 1/20 0.36
CDK1 P06493 1/20 0.36
PIM1 P11309 1/20 0.36
DYRK1A Q13627 1/20 0.36
PIM3 Q86V86 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GLA P06280 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
PTPN1 P18031 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5333975 0.84 MAPT (0.38) MAPT
SCHEMBL10866617 0.65 AHR (0.33) AHRALDH1A1
SCHEMBL207265 0.65 AHR (0.37) AHRPIM1MEN1NPC1ALDH1A1
SCHEMBL4152683 0.65 RAB9A (0.42) DYRK1AKDM4EMEN1NPC1ALDH1A1
SCHEMBL940594 0.63 ALDH1A1 (0.44) KDM4EMEN1NPC1ALDH1A1POLB
SCHEMBL407727 0.61 PKM (0.45) PIM1KDM4EMEN1RAB9AKMT2A
SCHEMBL19914339 0.60 AHR (0.42) AHRMAPK13CDK1PIM1DYRK1A
SCHEMBL10943939 0.60 CHRNB2 (0.42) AHRMAPK13CDK1PIM1DYRK1A
SCHEMBL12124147 0.59 MAPK13 (0.53) AHRMAPK13CDK1PIM1DYRK1A
SCHEMBL28696036 0.59 MAPK13 (0.46) AHRMAPK13CDK1PIM1DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030216571-A1 Antiallergens; antiinflammatory agents UBE INDUSTRIES, LTD. (JP) 2003-11-20 US claimed
EP-1254897-A1 TRICYCLIC COMPOUNDS Ube Industries, Ltd. (JP) 2002-11-06 EP claimed
US-7309718-B2 Dibenzocycloheptene compound UBE INDUSTRIES, LTD. (JP) 2007-12-18 US disclosed
US-20040180884-A1 Dibenzocycloheptene compound UBE INDUSTRIES, LTD. (JP) 2004-09-16 US disclosed
EP-1408033-A1 DIBENZOCYCLOHEPTENE COMPOUND Ube Industries, Ltd. (JP) 2004-04-14 EP disclosed
US-20030216571-A1 Antiallergens; antiinflammatory agents UBE INDUSTRIES, LTD. (JP) 2003-11-20 US disclosed
EP-1254897-A1 TRICYCLIC COMPOUNDS Ube Industries, Ltd. (JP) 2002-11-06 EP disclosed
US-4326065-A PLASTICS, VARNISHES, POLYESTERS EASTMAN KODAK COMPANY (US) 1982-04-20 US disclosed
US-4251433-A BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS EASTMAN KODAK COMPANY (US) 1981-02-17 US disclosed
US-4236013-A ADDITIVES FOR POLYMERS EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4172081-A Benzotriazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-10-23 US disclosed
US-4162254-A Benzoxazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-07-24 US disclosed
US-4137235-A ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1979-01-30 US disclosed
US-4116928-A Heterocylic ester, ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4116929-A POLYESTERS EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4096115-A Ultraviolet light stabilized polymers EASTMAN KODAK COMPANY (US) 1978-06-20 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4017508-A POLYMERS EASTMAN KODAK COMPANY (US) 1977-04-12 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040180884-A1 Dibenzocycloheptene compound LTB4R2, LTA4H, LTC4S AHR 273/4885MAPK13 1884/4885CDK1 1635/4885
US-20030216571-A1 Antiallergens; antiinflammatory agents CYSLTR2, CYSLTR1, LTC4S AHR 196/4885MAPK13 863/4885CDK1 1511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.