Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | USP7 | Q93009 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20797951 | 0.88 | ADCY10 (0.46) | ADCY10PTGS1PTGS2USP7KDM4E | |
| SCHEMBL20798092 | 0.80 | KDM4E (0.66) | ADCY10PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL15291855 | 0.79 | KDM4E (0.65) | ADCY10PTGS1PTGS2USP7KDM4E | |
| SCHEMBL23644542 | 0.78 | PTGS1 (0.54) | ADCY10PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL15720064 | 0.76 | MMP12 (0.48) | ADCY10PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL20798161 | 0.74 | ALDH1A1 (0.53) | ADCY10KDM4EALDH1A1GAACASP1 | |
| Hydrochloric Acid SCHEMBL5756808 | 0.74 | PTGS1 (0.56) | PTGS1PTGS2USP7KDM4EALDH1A1 | |
| SCHEMBL7675293 | 0.73 | CDK2 (0.56) | — | |
| SCHEMBL30714859 | 0.73 | ADCY10 (0.53) | ADCY10PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL19048703 | 0.70 | USP7 (0.76) | PTGS1PTGS2USP7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370769-B2 | TRPC5 inhibitors and methods of using same | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2022-06-28 | — | — | US | disclosed |
| EP-3678660-A1 | TRPC5 INHIBITORS AND METHODS OF USING SAME | Board of Regents of the University of Nebraska (US) | 2020-07-15 | — | — | EP | disclosed |
| US-20200216411-A1 | TRPC5 INHIBITORS AND METHODS OF USING SAME | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2020-07-09 | — | — | US | disclosed |
| WO-2019051197-A1 | TRPC5 INHIBITORS AND METHODS OF USING SAME | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2019-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200216411-A1 | TRPC5 INHIBITORS AND METHODS OF USING SAME | TRPC5, TRPC1, TRPC7 | ADCY10 2152/4885PTGS1 1462/4885PTGS2 1831/4885 |
| US-11370769-B2 | TRPC5 inhibitors and methods of using same | TRPC5, TRPC1, TRPC7 | ADCY10 2152/4885PTGS1 1462/4885PTGS2 1831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.