Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 7/20 | 0.40 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207457 | 0.85 | METAP2 (0.38) | MAP2K4AHRKDM4EDAOMETAP2 | |
| SCHEMBL6217817 | 0.75 | MAPT (0.42) | KDM4EMAPK1ACHE | |
| SCHEMBL208155 | 0.75 | DYRK1A (0.42) | AHRMETAP2CDK2CDK5 | |
| SCHEMBL2435236 | 0.75 | METAP2 (0.47) | MAP2K4METAP2MAPK1MAPK6 | |
| SCHEMBL2441098 | 0.74 | GPR84 (0.31) | GPR84 | |
| SCHEMBL406467 | 0.68 | MAPT (0.50) | DAO | |
| SCHEMBL7579630 | 0.64 | MEN1 (0.44) | KDM4EACHE | |
| SCHEMBL208707 | 0.64 | AHR (0.42) | MAP2K4AHRKDM4EDAOALPL | |
| SCHEMBL14485029 | 0.63 | GPR84 (0.42) | AHRGPR84MAPK1 | |
| SCHEMBL612070 | 0.62 | GPR84 (0.32) | DAOGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220048910-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2022-02-17 | — | — | US | claimed |
| EP-3946345-A1 | METHODS OF TREATING NEUROPATHIC PAIN | Intra-Cellular Therapies, Inc. (US) | 2022-02-09 | — | — | EP | claimed |
| CN-113905737-A | Method of treating neuropathic pain | 细胞内治疗公司 | 2022-01-07 | — | — | CN | claimed |
| EP-3914235-A2 | METHODS OF TREATING ADDICTION | Intra-Cellular Therapies, Inc. (US) | 2021-12-01 | — | — | EP | claimed |
| EP-3897621-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2021-10-27 | — | — | EP | claimed |
| CN-113329742-A | Method for treating addiction | 细胞内治疗公司 | 2021-08-31 | — | — | CN | claimed |
| WO-2020206391-A1 | METHODS OF TREATING NEUROPATHIC PAIN | INTRA-CELLULAR THERAPIES, INC. (US) | 2020-10-08 | — | — | WO | claimed |
| WO-2020154519-A2 | METHODS OF TREATING ADDICTION | INTRA-CELLULAR THERAPIES, INC. (US) | 2020-07-30 | — | — | WO | claimed |
| WO-2020132605-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2020-06-25 | — | — | WO | claimed |
| EP-0700396-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1996-03-13 | — | — | EP | claimed |
| US-5478845-A | Inhibit dopamine or 5-hydroxytryptamine receptor binding | NOVO NORDISK A/S (DK) | 1995-12-26 | — | — | US | claimed |
| WO-1994027994-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-12-08 | — | — | WO | claimed |
| CN-118105390-A | Method for treating addiction | 细胞内治疗公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117440774-A | Biomarkers of age-related macular degeneration | 倍亮生物有限责任公司 | 2024-01-23 | — | — | CN | disclosed |
| WO-2023069880-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| US-20220184072-A1 | METHODS OF TREATING NEUROPATHIC PAIN | INTRA-CELLULAR THERAPIES, INC. | 2022-06-16 | — | — | US | disclosed |
| US-5478845-A | Inhibit dopamine or 5-hydroxytryptamine receptor binding | NOVO NORDISK A/S (DK) | 1995-12-26 | — | — | US | disclosed |
| WO-1994027992-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-12-08 | — | — | WO | disclosed |
| WO-1994027994-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-12-08 | — | — | WO | disclosed |
| WO-1994027994-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220184072-A1 | METHODS OF TREATING NEUROPATHIC PAIN | GAP43, OPRK1, CNR2 | MAP2K4 3392/4885AHR 4251/4885KDM4E 3601/4885 |
| US-20220048910-A1 | ORGANIC COMPOUNDS | OPRD1, OPRM1, HTR2C | MAP2K4 1692/4885AHR 606/4885KDM4E 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.