Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | IL18 | Q14116 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21870896 | 0.86 | IDO1 (0.53) | IDO1DHODHSAE1UBA2ABCC9 | |
| SCHEMBL20941546 | 0.79 | IDO1 (0.53) | IDO1SAE1UBA2MAPTLMNA | |
| SCHEMBL11072625 | 0.79 | IDO1 (0.62) | IDO1DHODHSAE1UBA2MAPT | |
| SCHEMBL9726904 | 0.79 | IDO1 (0.61) | IDO1DHODHSAE1UBA2ABCC9 | |
| SCHEMBL5449567 | 0.78 | IDO1 (0.78) | IDO1DHODHSAE1UBA2ABCC9 | |
| SCHEMBL14266363 | 0.78 | SAE1 (0.57) | SAE1UBA2MAPTLMNATSHR | |
| SCHEMBL11063407 | 0.77 | CYP2A6 (0.63) | IDO1DHODHSAE1UBA2MAPT | |
| SCHEMBL22046676 | 0.76 | TAS2R38 (0.56) | MAPTHTTKMT2AKDM4EMAPK1 | |
| SCHEMBL21870897 | 0.76 | IDO1 (0.50) | IDO1DHODHSAE1UBA2ABCC9 | |
| SCHEMBL23866977 | 0.76 | IDO1 (0.58) | IDO1DHODHSAE1UBA2ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046670-B2 | Piperazinyl norbenzomorphan compounds and methods for using the same | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-06-29 | — | — | US | disclosed |
| US-10954217-B2 | Sigma receptor binders | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-03-23 | — | — | US | disclosed |
| US-10450275-B2 | Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-10-22 | — | — | US | disclosed |
| US-20190177301-A1 | SIGMA RECEPTOR BINDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-06-13 | — | — | US | disclosed |
| US-20190077789-A1 | PIPERAZINYL NORBENZOMORPHAN COMPOUNDS AND METHODS FOR USING THE SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077789-A1 | PIPERAZINYL NORBENZOMORPHAN COMPOUNDS AND METHODS FOR USING THE SAME | GAP43, NCDN, NLN | IDO1 3037/4885DHODH 819/4885SAE1 4869/4885 |
| US-11046670-B2 | Piperazinyl norbenzomorphan compounds and methods for using the same | GAP43, NCDN, NLN | IDO1 3037/4885DHODH 819/4885SAE1 4869/4885 |
| US-10954217-B2 | Sigma receptor binders | SIGMAR1, OPRK1, OPRL1 | IDO1 3255/4885DHODH 3670/4885SAE1 2417/4885 |
| US-20190177301-A1 | SIGMA RECEPTOR BINDERS | SIGMAR1, OPRK1, OPRL1 | IDO1 3255/4885DHODH 3670/4885SAE1 2417/4885 |
| US-10450275-B2 | Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain | ELAVL1, ADH1A, NGF | IDO1 1771/4885DHODH 2111/4885SAE1 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.