Sugi Predict

Sugi Predict / Compounds / SCHEMBL20818698

SCHEMBL20818698

SCHEMBL20818698

O=C1c2ccccc2C(=O)N1c1nn(Cc2ccccc2C(F)(F)F)c2c1CNCC2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR2C P28335 2/20 0.39
▸ HTR2B P41595 2/20 0.39
▸ CA12 O43570 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA9 Q16790 1/20 0.39
▸ HTR7 P34969 1/20 0.38
▸ TRPC5 Q9UL62 2/20 0.37
▸ TNKS O95271 1/20 0.35
▸ PARP1 P09874 1/20 0.35
▸ TNKS2 Q9H2K2 1/20 0.35
▸ CHRM5 P08912 1/20 0.35
▸ KMT2A Q03164 1/20 0.34
▸ GRIA2 P42262 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ P2RX7 Q99572 1/20 0.34
▸ P2RY14 Q15391 1/20 0.33
▸ SLC6A2 P23975 1/20 0.33
▸ SLC6A4 P31645 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25689110 0.85 HTR7 (0.40) HTR2CHTR2BCA12CA1CA9
SCHEMBL20818476 0.79 KDM4E (0.39) CA12CA1CA9TRPC5KMT2A
SCHEMBL31574237 0.78 FABP3 (0.42) HTR2CHTR2BHTR7KMT2ATDP1
SCHEMBL31574322 0.78 SCD (0.40) HTR2CHTR2BHTR7TRPC5PARP1
SCHEMBL20818579 0.75 CTSS (0.40) TRPC5PARP1TNKS2KMT2ATDP1
SCHEMBL20818110 0.74 KDM4E (0.44) HTR2CHTR2BHTR7KMT2ATDP1
SCHEMBL31574230 0.74 KDM4E (0.44) HTR2CHTR2BHTR7KMT2ATDP1
SCHEMBL20818480 0.71 TRPC5 (0.40) HTR2CHTR2BTRPC5KMT2ATDP1
SCHEMBL20817852 0.70 CYP3A4 (0.46) HTR2CCA12CA1CA9TNKS
SCHEMBL2075280 0.69 HTR7 (0.69) HTR2CHTR2BHTR7TRPC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435078-B2 Pyridazinones and methods of use thereof GFB (ABC), LLC (US) 2025-10-07 — — US disclosed
US-20230203028-A1 PYRIDAZINONES AND METHODS OF USE THEREOF GFB (ABC), LLC 2023-06-29 — — US disclosed
US-20230203028-A1 PYRIDAZINONES AND METHODS OF USE THEREOF GFB (ABC), LLC 2023-06-29 — — US disclosed
EP-3684364-A2 PYRIDAZINONES AND METHODS OF USE THEREOF Goldfinch Bio, Inc. (US) 2020-07-29 — — EP disclosed
WO-2019055966-A2 PYRIDAZINONES AND METHODS OF USE THEREOF GOLDFINCH BIO, INC. (US) 2019-03-21 — — WO disclosed
WO-2019055966-A2 PYRIDAZINONES AND METHODS OF USE THEREOF GOLDFINCH BIO, INC. (US) 2019-03-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230203028-A1 PYRIDAZINONES AND METHODS OF USE THEREOF PDXK, ATP6V1B1, REN HTR2C 489/4885HTR2B 380/4885CA12 4343/4885
US-12435078-B2 Pyridazinones and methods of use thereof PDXK, ATP6V1B1, REN HTR2C 489/4885HTR2B 380/4885CA12 4343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.