SCHEMBL20819554

SCHEMBL20819554

COC(C)(C)c1cccc(OC(C)Br)c1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 1/20 0.35
EDNRA P25101 1/20 0.35
PPARG P37231 4/20 0.32
PPARA Q07869 1/20 0.32
MTNR1A P48039 3/20 0.31
MTNR1B P49286 3/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
PTPN5 P54829 1/20 0.31
FFAR1 O14842 1/20 0.31
KIF11 P52732 1/20 0.31
MAPK1 P28482 1/20 0.31
TRPV1 Q8NER1 1/20 0.30
TAAR1 Q96RJ0 2/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20819610 0.83 NPSR1 (0.35) EDNRBEDNRAPPARGPPARACYP3A4
SCHEMBL20819533 0.80 PPARG (0.33) EDNRBEDNRAPPARGPPARAMTNR1A
SCHEMBL11748337 0.79 PPARG (0.49) PPARGPPARACYP2C19MAPT
SCHEMBL17911612 0.78 MTNR1A (0.40) MTNR1AMTNR1BTAAR1
SCHEMBL44954 0.75 MAPK1 (0.44) KIF11MAPK1TAAR1
SCHEMBL20819662 0.75 SOD1 (0.39) CYP3A4KIF11
SCHEMBL4572866 0.74 MTNR1A (0.50) MTNR1AMTNR1BCYP3A4TAAR1
SCHEMBL1547082 0.72 TP53 (0.50) CYP3A4CYP2C19MAPK1MAPT
SCHEMBL12500683 0.72 HDAC4 (0.44) CYP3A4PTPN5KIF11MAPK1MAPT
SCHEMBL3395414 0.71 ACHE (0.54) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3681864-A1 MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE AbbVie Overseas S.à r.l. (LU) 2020-07-22 EP disclosed
WO-2019053634-A1 MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE AbbVie S.à.r.l. (LU) 2019-03-21 WO disclosed