Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL208216 | 0.97 | MAPT (0.33) | MAPTFFAR3TSHRTP53CA2 | |
| Bicarbonate SCHEMBL1157519 | 0.97 | MAPT (0.33) | MAPTFFAR3TSHRTP53CA2 | |
| SCHEMBL124121 | 0.86 | — | — | |
| Benzene SCHEMBL190107 | 0.83 | TSHR (0.35) | MAPTTSHR | |
| Bicarbonate SCHEMBL27232679 | 0.78 | TSHR (0.35) | MAPTFFAR3TSHRTP53CA2 | |
| Bicarbonate SCHEMBL28959796 | 0.76 | FFAR3 (0.33) | MAPTFFAR3TSHRTP53CA2 | |
| Bicarbonate SCHEMBL29135929 | 0.76 | FFAR3 (0.33) | MAPTFFAR3TSHRTP53CA2 | |
| Bicarbonate SCHEMBL28422772 | 0.74 | FFAR3 (0.41) | FFAR3TSHRTP53CA2 | |
| Bicarbonate SCHEMBL28428212 | 0.74 | FFAR3 (0.41) | FFAR3TSHRTP53CA2 | |
| Isobutane SCHEMBL28428181 | 0.73 | FFAR3 (0.47) | FFAR3TSHRTP53CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255983-A1 | COMPOSITE PARTICLE AND USE THEREOF IN OPTICAL FILTRATION | Coloursmith Labs Inc. (CA) | 2023-10-11 | — | — | EP | claimed |
| WO-2022115948-A1 | COMPOSITE PARTICLE AND USE THEREOF IN OPTICAL FILTRATION | COLOURSMITH LABS INC. (CA) | 2022-06-09 | — | — | WO | claimed |
| US-20200388880-A1 | SILICON-BASED ENERGY STORAGE DEVICES WITH ELECTROLYTE ADDITIVE COMPOUNDS | ENEVATE CORPORATION | 2020-12-10 | — | — | US | claimed |
| EP-0810211-B1 | Organic peroxide stabilization with phosphomolybdic acid | CROMPTON CORP (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0853082-B1 | Organic peroxide stabilization with oximes | CROMPTON CORP (US) | 2001-03-14 | — | — | EP | claimed |
| EP-0810213-B1 | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | CK WITCO CORP (US) | 2000-09-06 | — | — | EP | claimed |
| EP-0810212-B1 | Organic peroxide stabilization with alpha-hydroxyalkyl peroxides | CK WITCO CORP (US) | 2000-04-05 | — | — | EP | claimed |
| US-5892090-A | Organic peroxide stabilization with oximes | WITCO CORPORATION (US) | 1999-04-06 | — | — | US | claimed |
| EP-0853082-A1 | Organic peroxide stabilization with oximes | WITCO CORPORATION (US) | 1998-07-15 | — | — | EP | claimed |
| US-5719304-A | Organic peroxide stabilization with phosphomolybdic acid | WITCO CORPORATION (US) | 1998-02-17 | — | — | US | claimed |
| US-5714626-A | PEROXYDICARBONATES OR DIACYL PEROXIDES AND CYCLIC OR ACYCLIC BETA-DICARBONYL STABILIZERS TO RETARD THE RATE OF DECOMPOSITON OF PEROXIDES WHICH ARE USED AS FREE-RADICAL INTITIATORS | WITCO CORPORATION (US) | 1998-02-03 | — | — | US | claimed |
| CN-1167760-A | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | WITCO CORP (US) | 1997-12-17 | — | — | CN | claimed |
| EP-0810211-A2 | Organic peroxide stabilization with phosphomolybdic acid | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | claimed |
| EP-0810213-A2 | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | claimed |
| EP-0810212-A2 | Organic peroxide stabilization with alpha-hydroxyalkyl peroxides | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | claimed |
| US-5654463-A | Organic peroxide stabilization with α-hydroxyalkyl peroxides | WITCO CORPORATION (US) | 1997-08-05 | — | — | US | claimed |
| US-5654464-A | RETARDING THE RATE OF DECOMPOSITION OF ESPECIALLY PEROXYDICARBONATE AND DIACYL PEROXIDE COMPOSITIONS; NONEXPLOSIVE; HEAT RESISTANCE; FREE RADICAL CATALYSTS; ADDITION POLYMERIZATION CATALYSTS | WITCO CORPORATION (US) | 1997-08-05 | — | — | US | claimed |
| US-4335230-A | FRRE RADICAL CATALYZED POLYMERIZATION OF ETHYLENICALLY UNDATURATED MONOMERS | AKZONA INCORPORATED (US) | 1982-06-15 | — | — | US | claimed |
| US-4269726-A | ACTIVATORS OR FREE RADICAL CATALYSTS POLYMERIZING VINYL CHLORIDE OR DIETHYLENE GLYCOL BIS/ALLYL CARBONATE/ | AKZONA INCORPORATED (US) | 1981-05-26 | — | — | US | claimed |
| US-12595356-B2 | Composite particle and use thereof in optical filtration | COLOURSMITH LABS INC. (CA) | 2026-04-07 | — | — | US | disclosed |
| EP-4685169-A1 | CLOSURE MEMBER FOR MANUFACTURING A POLYMERIC CAST SUBSTRATE | Essilor International (FR) | 2026-01-28 | — | — | EP | disclosed |
| US-12534548-B2 | Bleaching agent, preparation and use of the same with polymerizable compositions for optical materials | MITSUI CHEMICALS, INC. (JP) | 2026-01-27 | — | — | US | disclosed |
| US-12258428-B1 | Method for making smart optical materials by solution polymerization | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2025-03-25 | — | — | US | disclosed |
| US-20250002724-A1 | METHOD FOR MANUFACTURING AN OPTICAL MATERIAL AND COMPOSITION USED IN THIS METHOD | MITSUI CHEMICALS, INC. (JP) | 2025-01-02 | — | — | US | disclosed |
| US-12152091-B1 | Solution polymerization method for smart optical material | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2024-11-26 | — | — | US | disclosed |
| US-20240369740-A1 | Nanoparticles of Encapsulated Light-Absorbing Agent, Preparation Thereof and Ophthalmic Lens Comprising Said Nanoparticles | ESSILOR INTERNATIONAL (FR) | 2024-11-07 | — | — | US | disclosed |
| US-12110350-B1 | Smart optical material and method of making thereof | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2024-10-08 | — | — | US | disclosed |
| EP-4327139-A1 | METHOD FOR MANUFACTURING AN OPTICAL MATERIAL AND COMPOSITION USED IN THIS METHOD | Mitsui Chemicals, Inc. (JP) | 2024-02-28 | — | — | EP | disclosed |
| US-20240026127-A1 | COMPOSITE PARTICLE AND USE THEREOF IN OPTICAL FILTRATION | COLOURSMITH LABS INC. (CA) | 2024-01-25 | — | — | US | disclosed |
| CN-117003928-A | Composition for manufacturing an ophthalmic lens comprising an encapsulated light absorbing additive | 依视路国际公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-111433637-B | Composition for manufacturing an ophthalmic lens comprising an encapsulated light absorbing additive | 依视路国际公司 | 2023-11-03 | — | — | CN | disclosed |
| EP-4255983-A1 | COMPOSITE PARTICLE AND USE THEREOF IN OPTICAL FILTRATION | Coloursmith Labs Inc. (CA) | 2023-10-11 | — | — | EP | disclosed |
| US-11742519-B2 | Silicon-based energy storage devices with electrolyte additive compounds | ENEVATE CORPORATION (US) | 2023-08-29 | — | — | US | disclosed |
| CN-109642961-B | Composition for manufacturing an ophthalmic lens comprising an encapsulated light absorbing additive | 依视路国际公司 | 2023-07-14 | — | — | CN | disclosed |
| US-11635547-B2 | Composition for the manufacture of an ophthalmic lens comprising an encapsulated light-absorbing additive | ESSILOR INTERNATIONAL (FR) | 2023-04-25 | — | — | US | disclosed |
| EP-3497488-B2 | OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | ESSILOR INT (FR) | 2023-03-22 | — | — | EP | disclosed |
| US-20220403065-A1 | BLEACHING AGENT, PREPARATION AND USE OF THE SAME WITH POLYMERIZABLE COMPOSITIONS FOR OPTICAL MATERIALS | MITSUI CHEMICALS, INC. (JP) | 2022-12-22 | — | — | US | disclosed |
| WO-2022224928-A1 | METHOD FOR MANUFACTURING AN OPTICAL MATERIAL AND COMPOSITION USED IN THIS METHOD | MITSUI CHEMICALS, INC. (JP) | 2022-10-27 | — | — | WO | disclosed |
| EP-4058490-A1 | BLEACHING AGENT, PREPARATION AND USE OF THE SAME WITH POLYMERIZABLE COMPOSITIONS FOR OPTICAL MATERIALS | Mitsui Chemicals, Inc. (JP) | 2022-09-21 | — | — | EP | disclosed |
| CN-111566522-B | Nanoparticles of encapsulated light absorbers, their preparation and ophthalmic lenses comprising said nanoparticles | 依视路国际公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-109564297-B | Ophthalmic lenses comprising encapsulated light absorbing additives | 依视路国际公司 | 2022-08-16 | — | — | CN | disclosed |
| WO-2022115948-A1 | COMPOSITE PARTICLE AND USE THEREOF IN OPTICAL FILTRATION | COLOURSMITH LABS INC. (CA) | 2022-06-09 | — | — | WO | disclosed |
| CN-114599689-A | Bleaching agent, its preparation and its use with polymerizable compositions for optical materials | 三井化学株式会社 | 2022-06-07 | — | — | CN | disclosed |
| US-11327202-B2 | Composition for the manufacture of an ophthalmic lens comprising an encapsulated light-absorbing additive | ESSILOR INTERNATIONAL (FR) | 2022-05-10 | — | — | US | disclosed |
| US-11204445-B2 | Ophthalmic lens comprising an encapsulated light-absorbing additive | ESSILOR INTERNATIONAL (FR) | 2021-12-21 | — | — | US | disclosed |
| US-11046812-B2 | Polymerizable composition based on allyl carbonate monomers, polymerized product obtainable from said composition and uses thereof | MITSUI CHEMICALS, INC. (JP) | 2021-06-29 | — | — | US | disclosed |
| WO-2021095774-A1 | BLEACHING AGENT, PREPARATION AND USE OF THE SAME WITH POLYMERIZABLE COMPOSITIONS FOR OPTICAL MATERIALS | MITSUI CHEMICALS, INC. (JP) | 2021-05-20 | — | — | WO | disclosed |
| US-20210048559-A1 | Nanoparticles of Encapsulated Light-Absorbing Agent, Preparation Thereof and Ophthalmic Lens Comprising Said Nanoparticles | ESSILOR INTERNATIONAL (FR) | 2021-02-18 | — | — | US | disclosed |
| EP-3749990-A1 | NANOPARTICLES OF ENCAPSULATED LIGHT-ABSORBING AGENT, PREPARATION THEREOF AND OPHTHALMIC LENS COMPRISING SAID NANOPARTICLES | ESSILOR INTERNATIONAL (FR) | 2020-12-16 | — | — | EP | disclosed |
| US-20200386913-A1 | Composition for the Manufacture of an Ophthalmic Lens Comprising an Encapsulated Light-Absorbing Additive | ESSILOR INTERNATIONAL (FR) | 2020-12-10 | — | — | US | disclosed |
| US-20200388880-A1 | SILICON-BASED ENERGY STORAGE DEVICES WITH ELECTROLYTE ADDITIVE COMPOUNDS | ENEVATE CORPORATION | 2020-12-10 | — | — | US | disclosed |
| CN-111566522-A | Nanoparticles of encapsulated light absorbers, their preparation and ophthalmic lenses comprising said nanoparticles | 依视路国际公司 | 2020-08-21 | — | — | CN | disclosed |
| EP-3495853-B1 | COMPOSITION FOR THE MANUFACTURE OF AN OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | ESSILOR INT (FR) | 2020-07-29 | — | — | EP | disclosed |
| CN-111433637-A | Compositions for manufacturing ophthalmic lenses comprising encapsulated light absorbing additives | 依视路国际公司 | 2020-07-17 | — | — | CN | disclosed |
| EP-3497488-B1 | OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | ESSILOR INT (FR) | 2020-06-17 | — | — | EP | disclosed |
| EP-3436489-B1 | POLYMERIZABLE COMPOSITION BASED ON ALLYL CARBONATE MONOMERS, POLYMERIZED PRODUCT OBTAINABLE FROM SAID COMPOSITION AND USES THEREOF | MITSUI CHEMICALS INC (JP) | 2020-05-20 | — | — | EP | disclosed |
| US-20190212473-A1 | Ophthalmic Lens Comprising an Encapsulated Light-Absorbing Additive | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2019-07-11 | — | — | US | disclosed |
| EP-3497488-A1 | OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | Essilor International (FR) | 2019-06-19 | — | — | EP | disclosed |
| EP-3497487-A1 | COMPOSITION FOR THE MANUFACTURE OF AN OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | Essilor International (FR) | 2019-06-19 | — | — | EP | disclosed |
| WO-2019110264-A1 | COMPOSITION FOR THE MANUFACTURE OF AN OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | ESSILOR INTERNATIONAL (FR) | 2019-06-13 | — | — | WO | disclosed |
| EP-3495853-A1 | COMPOSITION FOR THE MANUFACTURE OF AN OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | Essilor International (FR) | 2019-06-12 | — | — | EP | disclosed |
| US-20190169438-A1 | Composition for the Manufacture of an Ophthalmic Lens Comprising an Encapsulated Light-Absorbing Additive | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2019-06-06 | — | — | US | disclosed |
| US-20190100617-A1 | POLYMERIZABLE COMPOSITION BASED ON ALLYL CARBONATE MONOMERS, POLYMERIZED PRODUCT OBTAINABLE FROM SAID COMPOSITION AND USES THEREOF | MITSUI CHEMICALS, INC. (JP) | 2019-04-04 | — | — | US | disclosed |
| EP-3282290-B1 | COMPOSITION FOR THE MANUFACTURE OF AN OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | ESSILOR INT (FR) | 2018-10-17 | — | — | EP | disclosed |
| EP-3282290-A1 | COMPOSITION FOR THE MANUFACTURE OF AN OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | Essilor International (FR) | 2018-02-14 | — | — | EP | disclosed |
| EP-2195351-A1 | POLYMERIZATION CONTROLLERS FOR COMPOSITES CURED BY ORGANIC PEROXIDE INITIATORS | Arkema, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009035821-A1 | POLYMERIZATION CONTROLLERS FOR COMPOSITES CURED BY ORGANIC PEROXIDE INITIATORS | ARKEMA INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20090065737-A1 | POLYMERIZATION CONTROLLERS FOR COMPOSITES CURED BY ORGANIC PEROXIDE INITIATORS | ARKEMA INC. (US) | 2009-03-12 | — | — | US | disclosed |
| EP-0810211-B1 | Organic peroxide stabilization with phosphomolybdic acid | CROMPTON CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0853082-B1 | Organic peroxide stabilization with oximes | CROMPTON CORP (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-0810213-B1 | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | CK WITCO CORP (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-0810212-B1 | Organic peroxide stabilization with alpha-hydroxyalkyl peroxides | CK WITCO CORP (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5892090-A | Organic peroxide stabilization with oximes | WITCO CORPORATION (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0853082-A1 | Organic peroxide stabilization with oximes | WITCO CORPORATION (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5719304-A | Organic peroxide stabilization with phosphomolybdic acid | WITCO CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| US-5714626-A | PEROXYDICARBONATES OR DIACYL PEROXIDES AND CYCLIC OR ACYCLIC BETA-DICARBONYL STABILIZERS TO RETARD THE RATE OF DECOMPOSITON OF PEROXIDES WHICH ARE USED AS FREE-RADICAL INTITIATORS | WITCO CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0810211-A2 | Organic peroxide stabilization with phosphomolybdic acid | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0810213-A2 | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0810212-A2 | Organic peroxide stabilization with alpha-hydroxyalkyl peroxides | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5654463-A | Organic peroxide stabilization with α-hydroxyalkyl peroxides | WITCO CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5654464-A | RETARDING THE RATE OF DECOMPOSITION OF ESPECIALLY PEROXYDICARBONATE AND DIACYL PEROXIDE COMPOSITIONS; NONEXPLOSIVE; HEAT RESISTANCE; FREE RADICAL CATALYSTS; ADDITION POLYMERIZATION CATALYSTS | WITCO CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0032757-B2 | AQUEOUS PEROXIDE EMULSION AND ITS USE IN SUSPENSION (CO)POLYMERIZATION REACTIONS | AKZO N.V. (NL) | 1990-03-07 | — | — | EP | disclosed |
| EP-0032757-B1 | AQUEOUS PEROXIDE EMULSION AND ITS USE IN SUSPENSION (CO)POLYMERIZATION REACTIONS | AKZO N.V. (NL) | 1983-03-23 | — | — | EP | disclosed |
| EP-0031975-B1 | A PEROXYDICARBONATE COMPOSITION AND ITS USE FOR POLYMERIZING ETHYLENICALLY UNSATURATED COMPOUNDS | AKZO N.V. (NL) | 1983-02-16 | — | — | EP | disclosed |
| US-4335230-A | FRRE RADICAL CATALYZED POLYMERIZATION OF ETHYLENICALLY UNDATURATED MONOMERS | AKZONA INCORPORATED (US) | 1982-06-15 | — | — | US | disclosed |
| EP-0032757-A2 | Aqueous peroxide emulsion and its use in suspension (co)polymerization reactions | AKZO N.V. (NL) | 1981-07-29 | — | — | EP | disclosed |
| EP-0031975-A1 | A peroxydicarbonate composition and its use for polymerizing ethylenically unsaturated compounds | AKZO N.V. (NL) | 1981-07-15 | — | — | EP | disclosed |
| US-4269726-A | ACTIVATORS OR FREE RADICAL CATALYSTS POLYMERIZING VINYL CHLORIDE OR DIETHYLENE GLYCOL BIS/ALLYL CARBONATE/ | AKZONA INCORPORATED (US) | 1981-05-26 | — | — | US | disclosed |
| US-4269726-A | ACTIVATORS OR FREE RADICAL CATALYSTS POLYMERIZING VINYL CHLORIDE OR DIETHYLENE GLYCOL BIS/ALLYL CARBONATE/ | AKZONA INCORPORATED (US) | 1981-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200388880-A1 | SILICON-BASED ENERGY STORAGE DEVICES WITH ELECTROLYTE ADDITIVE COMPOUNDS | SOST, CA1, DUOX2 | MAPT 3895/4885FFAR3 3894/4885TSHR 4386/4885 |
| US-11742519-B2 | Silicon-based energy storage devices with electrolyte additive compounds | SOST, CA1, DUOX2 | MAPT 3895/4885FFAR3 3894/4885TSHR 4386/4885 |
| US-12595356-B2 | Composite particle and use thereof in optical filtration | CHLSN, PPOX, AHR | MAPT 2815/4885FFAR3 1541/4885TSHR 728/4885 |
| US-12534548-B2 | Bleaching agent, preparation and use of the same with polymerizable compositions for optical materials | HBB, HBZ, CASP12 | MAPT 1547/4885FFAR3 1331/4885TSHR 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.