Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | RGS12 | O14924 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20820817 | 0.87 | DGAT1 (0.50) | DGAT1HDAC6SLC2A1RGS12HDAC3 | |
| SCHEMBL20828341 | 0.79 | DGAT1 (0.48) | DGAT1HDAC6SLC2A1KDM4EKMT2A | |
| SCHEMBL20828420 | 0.78 | DGAT1 (0.47) | DGAT1HDAC6SLC2A1KDM4EKMT2A | |
| SCHEMBL20828421 | 0.77 | SCD (0.43) | DGAT1HDAC6SLC2A1ALDH1A1KMT2A | |
| SCHEMBL20828417 | 0.76 | ROCK2 (0.46) | DGAT1SLC2A1KMT2AMEN1MAPK1 | |
| SCHEMBL20828346 | 0.76 | DGAT1 (0.52) | DGAT1HDAC6RGS12KDM4EALDH1A1 | |
| SCHEMBL19197479 | 0.75 | TRPV1 (0.61) | HDAC6KMT2AMEN1HDAC3HDAC1 | |
| SCHEMBL20828343 | 0.75 | DGAT1 (0.42) | DGAT1HDAC6SLC2A1ALDH1A1MCHR1 | |
| SCHEMBL20828418 | 0.75 | DGAT1 (0.44) | DGAT1SLC2A1KMT2AMEN1 | |
| SCHEMBL6407016 | 0.73 | DGAT1 (0.63) | DGAT1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019054430-A1 | AMIDE COMPOUND HAVING AROMATIC HETEROCYCLE | 第一三共株式会社 | 2019-03-21 | — | — | WO | disclosed |