Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819184 | 0.90 | PORCN (0.65) | PORCNALOX15TP53LMNACYP1A2 | |
| SCHEMBL20819142 | 0.89 | PORCN (0.79) | PORCNALOX15TP53LMNACYP1A2 | |
| SCHEMBL30145219 | 0.89 | PORCN (0.79) | PORCNALOX15TP53LMNACYP1A2 | |
| Etc-159 SCHEMBL29381546 | 0.85 | PORCN (1.00) | PORCNALOX15TP53CYP1A2RXFP1 | |
| Etc-159 SCHEMBL17626176 | 0.85 | PORCN (1.00) | PORCNALOX15TP53CYP1A2RXFP1 | |
| SCHEMBL10114488 | 0.83 | ALOX15 (1.00) | ALOX15TP53LMNACYP1A2RXFP1 | |
| SCHEMBL17626253 | 0.83 | ALOX15 (0.74) | PORCNALOX15TP53LMNACYP1A2 | |
| SCHEMBL18166728 | 0.83 | LMNA (0.79) | ALOX15TP53LMNACYP1A2RXFP1 | |
| SCHEMBL22375237 | 0.82 | PORCN (0.71) | PORCNALOX15TP53CYP1A2RXFP1 | |
| SCHEMBL17628692 | 0.82 | PORCN (0.82) | PORCNALOX15TP53CYP1A2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186581-B2 | 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-hydroxyphenyl)pyridazin-3-yl)acetamide as a Wnt pathway modulator | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2021-11-30 | — | — | US | disclosed |
| US-20200270255-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2020-08-27 | — | — | US | disclosed |
| WO-2019054941-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270255-A1 | WNT PATHWAY MODULATORS | WNT1, WNT3A, WNT3 | PORCN 3838/4885ALOX15 910/4885TP53 422/4885 |
| US-11186581-B2 | 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-hydroxyphenyl)pyridazin-3-yl)acetamide as a Wnt pathway modulator | WNT1, WNT3A, WNT3 | PORCN 3817/4885ALOX15 918/4885TP53 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.