SCHEMBL20835006

SCHEMBL20835006

Cc1ccc(C#Cc2cc(F)c(SC#N)c(F)c2)c(C)c1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 3/20 0.32
FFAR4 Q5NUL3 2/20 0.32
AR P10275 2/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
ALOX12 P18054 1/20 0.32
BRCA1 P38398 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20834872 0.84 FFAR1 (0.34) FFAR1FFAR4ALDH1A1
SCHEMBL20834905 0.84 TRPA1 (0.30) FFAR1
SCHEMBL20834697 0.84 FFAR1 (0.34) FFAR1FFAR4
SCHEMBL19465072 0.83 ALDH1A1 (0.39) FFAR1FFAR4ALDH1A1
SCHEMBL21399529 0.83 ALDH1A1 (0.39) FFAR1FFAR4ALDH1A1
SCHEMBL24940631 0.83 CYP11B1 (0.39) FFAR1FFAR4ARMEN1KMT2A
SCHEMBL20834706 0.83 HTR1A (0.30)
SCHEMBL20834691 0.82
SCHEMBL23395480 0.81 RAPGEF4 (0.30)
SCHEMBL20228293 0.79 ALDH1A1 (0.36) FFAR1ARALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4137552-A1 LIQUID CRYSTAL COMPOSITION HAVING EXTREMELY LOW DIELECTRIC LOSS, AND HIGH-FREQUENCY COMPONENT COMPRISING SAME Xi'an Modern Chemistry Research Institute (CN) 2023-02-22 EP disclosed
EP-3681976-B1 ISOTHIOCYANATO TOLANE DERIVATIVES MERCK PATENT GMBH (DE) 2021-05-26 EP disclosed
WO-2019052972-A1 ISOTHIOCYANATO TOLANE DERIVATIVES MERCK PATENT GMBH (DE) 2019-03-21 WO disclosed