Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697698 | 0.78 | MAPT (0.51) | MAPTNR4A2KDM4ETDP1L3MBTL1 | |
| SCHEMBL22710270 | 0.76 | MAPT (0.68) | MAPTNR4A2KDM4EL3MBTL1CCR1 | |
| SCHEMBL11557724 | 0.74 | NR4A2 (0.59) | MAPTNR4A2KDM4ETDP1L3MBTL1 | |
| SCHEMBL4738026 | 0.74 | MAPT (0.66) | MAPTNR4A2KDM4EL3MBTL1CCR1 | |
| SCHEMBL10698717 | 0.74 | KDM4E (0.49) | MAPTNR4A2KDM4ETDP1L3MBTL1 | |
| SCHEMBL9860481 | 0.73 | G6PD (0.49) | MAPTNR4A2KDM4ETDP1TSHR | |
| SCHEMBL20838508 | 0.72 | CTSB (0.52) | MAPTKDM4ETDP1L3MBTL1HTT | |
| SCHEMBL439768 | 0.71 | NR4A2 (0.65) | MAPTNR4A2KDM4ETDP1L3MBTL1 | |
| SCHEMBL10698901 | 0.70 | CCR1 (0.46) | MAPTNR4A2KDM4ETDP1L3MBTL1 | |
| SCHEMBL1562545 | 0.69 | KMT2A (0.60) | MAPTNR4A2KDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466931-B1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | UNIV GUANGDONG TECHNOLOGY (CN) | 2024-01-10 | — | — | EP | disclosed |
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | UNIV GUANGDONG TECHNOLOGY (CN) | 2020-10-20 | — | — | US | disclosed |
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | UNIV GUANGDONG TECHNOLOGY (CN) | 2020-10-20 | — | — | US | disclosed |
| EP-3466931-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | Guangdong University Of Technology (CN) | 2019-04-10 | — | — | EP | disclosed |
| EP-3466931-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | Guangdong University Of Technology (CN) | 2019-04-10 | — | — | EP | disclosed |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | GUANGDONG UNIVERSITY OF TECHNOLOGY | 2019-03-28 | — | — | US | disclosed |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | GUANGDONG UNIVERSITY OF TECHNOLOGY | 2019-03-28 | — | — | US | disclosed |
| CN-105949120-A | Four-tooth chelating single quinoline derivative, preparation method thereof and application as metal ion regulator for neurodegenerative disease | 广东工业大学 | 2016-09-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | SOD1, SLC30A6, SLC30A7 | MAPT 31/4885NR4A2 2889/4885KDM4E 2023/4885 |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | SOD1, SLC30A6, SLC30A7 | MAPT 31/4885NR4A2 2889/4885KDM4E 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.