Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Temefos. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Temefos SCHEMBL44105 | 0.78 | LMNA (0.53) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL23303378 | 0.78 | LMNA (0.53) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL6388031 | 0.77 | LMNA (0.51) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL8741692 | 0.77 | LMNA (0.51) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL9193178 | 0.76 | LMNA (0.54) | LMNASMN1; SMN2THRBALDH1A1CYP3A4 | |
| Temefos SCHEMBL10455340 | 0.76 | LMNA (0.47) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL117778 | 0.74 | LMNA (0.40) | LMNASMN1; SMN2THRBHDAC1HDAC2 | |
| Temefos SCHEMBL15553439 | 0.73 | LMNA (0.51) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL20919592 | 0.72 | ALDH1A1 (0.46) | LMNASMN1; SMN2THRBTDP1ALDH1A1 | |
| Temefos SCHEMBL9809762 | 0.72 | LMNA (0.42) | LMNASMN1; SMN2THRBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684365-A1 | PROTEIN DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-07-29 | — | — | EP | disclosed |
| WO-2019060742-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC (US) | 2019-03-28 | — | — | WO | disclosed |