Temefos

Temefos

SCHEMBL117778

COP(=S)(OC)Oc1ccc(Sc2ccc(OP(=S)(OC)OC)cc2)cc1.NCCCC(=O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.40
THRB P10828 4/20 0.40
ALDH1A1 P00352 4/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
CYP3A4 P08684 2/20 0.40
HSD17B10 Q99714 2/20 0.40
TP53 P04637 1/20 0.40
MAPK1 P28482 1/20 0.40
NPSR1 Q6W5P4 3/20 0.39
TSHR P16473 2/20 0.39
BLM P54132 2/20 0.39
KMT2A Q03164 2/20 0.39
GABRR3 A8MPY1 1/20 0.39
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
HDAC3 O15379 1/20 0.39
GABBR2 O75899 1/20 0.39
CYP1A2 P05177 1/20 0.39
GABRA1 P14867 1/20 0.39
GABRB1 P18505 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Temefos SCHEMBL44105 0.78 LMNA (0.53) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL23303378 0.78 LMNA (0.53) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL8741692 0.77 LMNA (0.51) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL6388031 0.77 LMNA (0.51) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL9193178 0.76 LMNA (0.54) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL10455340 0.76 LMNA (0.47) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL9809762 0.75 LMNA (0.42) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL20840360 0.74 LMNA (0.47) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL9435846 0.70 LMNA (0.40) LMNATHRBALDH1A1SMN1; SMN2CYP3A4
Temefos SCHEMBL20919592 0.70 ALDH1A1 (0.46) LMNATHRBALDH1A1SMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022150559-A1 METHODS FOR TREATMENT OF CANCER USING ABL INHIBITORS AND DRUGS TARGETING THE MEVALONATE PATHWAY DUKE UNIVERSITY (US) 2022-07-14 WO disclosed
EP-3813949-A1 ENERGETIC\" CANCER STEM CELLS (E-CSCS): A NEW HYPER-METABOLIC AND PROLIFERATIVE TUMOR CELL PHENOTYPE, DRIVEN BY MITOCHONDRIAL ENERGY Lunella Biotech, Inc. (CA) 2021-05-05 EP disclosed
EP-3695005-A1 ANTI-MITOCHONDRIAL INHIBITORS FOR ONCOGENIC RAS AND MYC Lunella Biotech, Inc. (CA) 2020-08-19 EP disclosed
EP-3612187-A1 VITAMIN C AND DOXYCYCLINE: A SYNTHETIC LETHAL COMBINATION THERAPY FOR ERADICATING CANCER STEM CELLS (CSCS) Lunella Biotech, Inc. (CA) 2020-02-26 EP disclosed
EP-3612177-A1 TARGETING HYPOXIC CANCER STEM CELLS (CSCS) WITH DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY Lunella Biotech, Inc. (CA) 2020-02-26 EP disclosed
EP-3490581-A2 NEUROMODULATING COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF CANCER Flagship Pioneering Innovations V, Inc. (US) 2019-06-05 EP disclosed
WO-2019075219-A1 ANTI-MITOCHONDRIAL INHIBITORS FOR ONCOGENIC RAS AND MYC LUNELLA BIOTECH, INC. (CA) 2019-04-18 WO disclosed
WO-2019075209-A1 ANTI-MITOCHONDRIAL INHIBITORS FOR ONCOGENIC RAS AND MYC LUNELLA BIOTECH, INC. (CA) 2019-04-18 WO disclosed
WO-2019075226-A1 ANTI-MITOCHONDRIAL INHIBITORS FOR ONCOGENIC RAS AND MYC LUNELLA BIOTECH, INC. (CA) 2019-04-18 WO disclosed
EP-3442706-A1 SAMPLE COLLECTION AND PRESERVATION DEVICES, SYSTEMS AND METHODS NextGen Jane, Inc. (US) 2019-02-20 EP disclosed
WO-2012120301-A1 EVALUATION OF THERAPEUTIC AGENT DUNDEE CELL PRODUCTS LIMITED (GB) 2012-09-13 WO disclosed
EP-2425021-A1 INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES Nuvera Biosciences, Inc. (US) 2012-03-07 EP disclosed
WO-2011120984-A1 METHOD FOR BREAST CANCER RECURRENCE PREDICTION UNDER ENDOCRINE TREATMENT SIVIDON DIAGNOSTICS GMBH (DE) 2011-10-06 WO disclosed
WO-2010127338-A1 INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES NUVERA BIOSCIENCES, INC. (US) 2010-11-04 WO disclosed
EP-1880332-A2 NOVEL METHODS AND DEVICES FOR EVALUATING POISONS Emiliem (US) 2008-01-23 EP disclosed
US-20070259363-A1 Phylogenetic Analysis of Mass Spectrometry or Gene Array Data for the Diagnosis of Physiological Conditions AMRI HAKIMA 2007-11-08 US disclosed
WO-2006116622-A2 NOVEL METHODS AND DEVICES FOR EVALUATING POISONS EMILIEM (US) 2006-11-02 WO disclosed
EP-1599607-A2 SIGNATURES OF ER STATUS IN BREAST CANCER Arcturus Bioscience, Inc. (US) 2005-11-30 EP disclosed
US-20050208500-A1 Signatures of ER status in breast cancer ARCUTURUS BIOSCIENCE, INC. 2005-09-22 US disclosed
WO-2004079014-A2 SIGNATURES OF ER STATUS IN BREAST CANCER ARCTURUS BIOSCIENCE, INC. (US) 2004-09-16 WO disclosed