Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20845698 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL22375194 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL6238315 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL28754267 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL4660520 | 0.82 | CYP1A2 (0.43) | ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL4660647 | 0.82 | PLAAT3 (0.45) | ALDH1A1FFAR1HDAC2HDAC8HDAC6 | |
| SCHEMBL4660802 | 0.82 | CYP1A2 (0.43) | ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL4659398 | 0.82 | PLAAT3 (0.45) | ALDH1A1FFAR1HDAC2HDAC8HDAC6 | |
| SCHEMBL4660629 | 0.80 | TAAR1 (0.50) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL4824729 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KEAP1FFAR1TDP1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332426-B2 | Method of preparing trisubstituted ethylene compounds | TRUSTEES OF BOSTON COLLEGE (US) | 2022-05-17 | — | — | US | disclosed |
| US-20200270194-A1 | METHOD OF PREPARING TRISUBSTITUTED ETHYLENE COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-08-27 | — | — | US | disclosed |
| EP-3684750-A1 | METHOD OF PREPARING TRISUBSTITUTED ETHYLENE COMPOUNDS | Trustees of Boston College (US) | 2020-07-29 | — | — | EP | disclosed |
| WO-2019060749-A1 | METHOD OF PREPARING TRISUBSTITUTED ETHYLENE COMPOUNDS | TRUSTEES OF BOSTON COLLEGE (US) | 2019-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332426-B2 | Method of preparing trisubstituted ethylene compounds | EMC1, EMC2, ESR1 | ALDH1A1 3441/4885KEAP1 285/4885FFAR1 4438/4885 |
| US-20200270194-A1 | METHOD OF PREPARING TRISUBSTITUTED ETHYLENE COMPOUNDS | ESR1, EMC1, EMC2 | ALDH1A1 3202/4885KEAP1 238/4885FFAR1 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.