SCHEMBL20847646

SCHEMBL20847646

Fc1c(F)c(F)c(SN(Cc2cnccc2C(F)(F)F)C2CC2)c(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.36
FAAH O00519 1/20 0.32
MAPT P10636 2/20 0.32
GSK3A P49840 1/20 0.32
GSK3B P49841 1/20 0.32
PRKCQ Q04759 9/20 0.32
PRKCD Q05655 7/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
RBP4 P02753 1/20 0.32
C5AR1 P21730 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
TRPA1 O75762 1/20 0.32
SCD O00767 1/20 0.31
SCD5 Q86SK9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20847650 0.77 ALDH1A1 (0.35) TRPA1
SCHEMBL20847643 0.75 CXCR4 (0.37) SLC6A2SLC6A4
SCHEMBL20847649 0.74 HDAC6 (0.46) GAAMAPTSLC6A2SLC6A4
SCHEMBL20847761 0.72 SLC6A2 (0.40) MAPTSLC6A2SLC6A4
SCHEMBL23793573 0.71 MAPT (0.35) FAAHMAPTPRKCQPRKCDSCD
SCHEMBL20847477 0.70 SLC6A2 (0.39) SLC6A2SLC6A4
SCHEMBL20847474 0.69 SLC6A2 (0.42) SLC6A2SLC6A4TRPA1
SCHEMBL23792683 0.69 CD38 (0.36) PRKCQPRKCD
SCHEMBL20847720 0.69 ALDH1A1 (0.41) MAPTSLC6A2SLC6A4
SCHEMBL20847629 0.69 HTR2A (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019056120-A1 PENTAFLUOROPHENYL SULFONAMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF DALRIADA THERAPEUTICS INC. (CA) 2019-03-28 WO disclosed