Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | VCP | P55072 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087784 | 1.00 | CYP3A4 (0.67) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| SCHEMBL2094647 | 0.88 | KDM4E (0.59) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| SCHEMBL2094645 | 0.88 | KDM4E (0.59) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| SCHEMBL19472000 | 0.87 | CYP19A1 (0.78) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| SCHEMBL29108872 | 0.81 | CYP3A4 (0.62) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| SCHEMBL28837107 | 0.80 | CYP3A4 (0.67) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| Isosafrole SCHEMBL345862 | 0.80 | CYP3A4 (1.00) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| Isosafrole SCHEMBL30302237 | 0.80 | CYP3A4 (1.00) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| SCHEMBL7977301 | 0.80 | CYP3A4 (0.67) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 | |
| Isosafrole SCHEMBL7075676 | 0.80 | CYP3A4 (1.00) | CYP3A4ATMCYP19A1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112939778-B | Coumarin compound ester derivatives, preparation method and application thereof | 西北农林科技大学 | 2022-08-02 | — | — | CN | claimed |
| CN-112939778-A | Coumarin compound ester derivatives, preparation method and application thereof | 西北农林科技大学 | 2021-06-11 | — | — | CN | claimed |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | HAMILTON GREGORY S | 2008-03-27 | — | — | US | claimed |
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | claimed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | claimed |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 2004-03-11 | — | — | US | claimed |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | GLIAMED, INC. | 2002-12-26 | — | — | US | claimed |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | GPL NIL HOLDINGS, INC., | 2001-12-06 | — | — | US | claimed |
| US-20010034362-A1 | Pyrrolidine derivatives for vision and memory disorders | GUILFORD PHARMACEUTICALS INC. (US) | 2001-10-25 | — | — | US | claimed |
| US-6239164-B1 | IMMUNOPHILIN AFFINITY; NONIMMUNOSUPPRESSANT | GPI NIL HOLDINGS, INC. | 2001-05-29 | — | — | US | claimed |
| US-6218423-B1 | ADMINISTERING PYRROLIDINE DERIVATIVE FOR THERAPY OF NERVE-RELATED VISION DISORDER, IMPROVING VISION, TREATING MEMORY IMPAIRMENT, OR ENHANCING MEMORY PERFORMANCE IN ANIMAL | GPI NIL HOLDINGS, INC. | 2001-04-17 | — | — | US | claimed |
| US-6177455-B1 | ADMINISTERING A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | GPI NIL HOLDINGS, INC. | 2001-01-23 | — | — | US | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | claimed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | claimed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | CYP3A4 4866/4885ATM 3476/4885CYP19A1 4544/4885 |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP14, PREP | CYP3A4 3357/4885ATM 4791/4885CYP19A1 2463/4885 |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | CYP3A4 2089/4885ATM 4611/4885CYP19A1 171/4885 |
| US-20010034362-A1 | Pyrrolidine derivatives for vision and memory disorders | PDE6D, PDE6C, PDE4D | CYP3A4 3462/4885ATM 3530/4885CYP19A1 3357/4885 |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | FKBP8, FKBP1A, FKBP2 | CYP3A4 3508/4885ATM 4798/4885CYP19A1 2303/4885 |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | CYP3A4 2089/4885ATM 4611/4885CYP19A1 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.