Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.67 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.67 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.67 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | CETP | P11597 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | DDX3X | O00571 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706504 | 0.87 | CETP (0.71) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL6349201 | 0.86 | PDK1 (0.70) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL26623837 | 0.85 | PDK1 (0.73) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL8347800 | 0.85 | PDK1 (0.63) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL21861381 | 0.84 | POLB (0.55) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL2087952 | 0.83 | CETP (0.67) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL28577700 | 0.83 | PDK1 (0.50) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL11245698 | 0.83 | PDK1 (0.61) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL11173223 | 0.83 | PDK1 (0.61) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL914296 | 0.82 | PDK1 (0.70) | PDK1PDK2PDK3PDK4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 319 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113024399-B | Pharmaceutical intermediate compound and preparation method and application thereof | 华东理工大学 | 2022-09-09 | — | — | CN | claimed |
| US-5489681-A | Method for the preparation of 4-phenyl-1,3-benzodiazepins | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-02-06 | — | — | US | claimed |
| US-5349086-A | Method for the preparation of 4-phenyl-1,3-benzodiazepins and precursors thereof | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-09-20 | — | — | US | claimed |
| US-4461728-A | Preparation of 4-phenyl-1,3-benzodiazepins | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1984-07-24 | — | — | US | claimed |
| EP-4591314-A2 | SELECTION OF CHEMICAL SYNTHESIS PROCESSES | The Regents of The University of Michigan (US) | 2025-07-30 | — | — | EP | disclosed |
| US-RE50453-E1 | Indole derivatives as CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-06-10 | — | — | US | disclosed |
| WO-2024064884-A2 | SELECTION OF CHEMICAL SYNTHESIS PROCESSES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |
| US-20240092766-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2024-03-21 | — | — | US | disclosed |
| CN-117567350-A | Preparation method of indolone compound | 暨南大学 | 2024-02-20 | — | — | CN | disclosed |
| US-20230337677-A1 | ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2023-10-26 | — | — | US | disclosed |
| US-11664093-B2 | Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-05-30 | — | — | US | disclosed |
| US-11639347-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-05-02 | — | — | US | disclosed |
| US-4709093-A | Method for the preparation of 4-phenyl-1,3-benzodiazepines and precursors thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-11-24 | — | — | US | disclosed |
| EP-0082523-B1 | INTERMEDIATES FOR THE PREPARATION OF 4-PHENYL-1,3-BENZODIAZEPINS AND METHODS FOR PREPARING THE INTERMEDIATES | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-04-02 | — | — | EP | disclosed |
| EP-0066773-B1 | N-(2-(2-AMINO-2-PHENYLETHYL)PHENYL)-2,2-DIMETHYL-PROPANAMID AND DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-09-05 | — | — | EP | disclosed |
| US-4461728-A | Preparation of 4-phenyl-1,3-benzodiazepins | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1984-07-24 | — | — | US | disclosed |
| EP-0082523-A2 | Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-06-29 | — | — | EP | disclosed |
| US-4374067-A | Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-02-15 | — | — | US | disclosed |
| EP-0066773-A1 | N-(2-(2-amino-2-phenylethyl)phenyl)-2,2-dimethyl-propanamid and derivatives and a process for preparing the same | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-12-15 | — | — | EP | disclosed |
| US-3987059-A | ALKYL LITHIUM, CYCLIZATION, DEMETALLIZATION | SANDOZ, INC. (US) | 1976-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092766-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | PDK1 2295/4885PDK2 3693/4885PDK3 3477/4885 |
| US-11639347-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | PDK1 2295/4885PDK2 3693/4885PDK3 3477/4885 |
| US-20230337677-A1 | ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF | DDT, ACHE, AHR | PDK1 2357/4885PDK2 1573/4885PDK3 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.