SCHEMBL20895237

SCHEMBL20895237

Fc1ccc(-c2ccnc3s[c]cc23)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 1/20 0.40
MAPK14 Q16539 3/20 0.37
ALDH1A1 P00352 5/20 0.36
SMN1; SMN2 Q16637 4/20 0.36
KDM4E B2RXH2 3/20 0.36
GAA P10253 1/20 0.36
RAB9A P51151 3/20 0.35
CYP17A1 P05093 3/20 0.34
MAPT P10636 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
LMNA P02545 2/20 0.34
NPC1 O15118 2/20 0.34
NFKB1 P19838 2/20 0.34
NFKB2 Q00653 2/20 0.34
RELA Q04206 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CDK2 P24941 2/20 0.33
CYP1A2 P05177 2/20 0.33
GRM4 Q14833 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18889257 0.70 SLC9A1 (0.41) RIPK1MAPK14CYP17A1CDK7NR4A2
SCHEMBL3356148 0.70 GLO1 (0.43) MAPK14ALDH1A1SMN1; SMN2KDM4EGAA
SCHEMBL20895111 0.68 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2RAB9ACYP17A1MEN1
SCHEMBL20895186 0.68 PTGS2 (0.35) ALDH1A1SMN1; SMN2KDM4ERAB9ALMNA
SCHEMBL20895093 0.68 GSK3A (0.48) MAPK14SMN1; SMN2CYP17A1CDK2CDK1
SCHEMBL18889227 0.66 RIPK1 (0.64) RIPK1MAPK14KDM4EMAPTLMNA
SCHEMBL5318173 0.66 GRM4 (0.62) MAPK14RAB9AMAPTCYP1A2GRM4
SCHEMBL18805529 0.66 GRM4 (0.62) MAPK14RAB9AMAPTCYP1A2GRM4
SCHEMBL6660966 0.66 GRM4 (0.56) GRM4CDK1CCNB1
SCHEMBL31014179 0.66 GRM4 (0.62) MAPK14RAB9AMAPTCYP1A2GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3176163-B1 NOVEL INDENE DERIVATIVE, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITION, FOR PREVENTING OR TREATING RETINAL DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT IAC IN NAT UNIV CHUNGNAM (KR) 2019-04-17 EP claimed
EP-3176163-B1 NOVEL INDENE DERIVATIVE, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITION, FOR PREVENTING OR TREATING RETINAL DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT IAC IN NAT UNIV CHUNGNAM (KR) 2019-04-17 EP disclosed