SCHEMBL2090993

SCHEMBL2090993

[CH2]C(=O)c1ccc(C)cc1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.47
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
HTT P42858 2/20 0.46
HSD11B1 P28845 1/20 0.45
TP53 P04637 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
ALDH1A1 P00352 2/20 0.43
FLT1 P17948 1/20 0.42
FLT4 P35916 1/20 0.42
KDR P35968 1/20 0.42
CSNK2A1 P68400 1/20 0.42
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
TAS1R2 Q8TE23 1/20 0.41
THRB P10828 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2092006 0.82 MEN1 (0.53) KMT2AMEN1SMN1; SMN2ALDH1A1CSNK2A1
SCHEMBL31369141 0.81 LMNA (0.50) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL286054 0.81 LMNA (0.50) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL9420260 0.81 NFE2L2 (0.55) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL107259 0.79 CSNK2A1 (0.59) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL30679777 0.79 CSNK2A1 (0.59) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL501730 0.79 NFE2L2 (0.49) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL29381894 0.79 KMT2A (0.51) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL96218 0.79 KMT2A (0.51) NFE2L2KMT2AMEN1SMN1; SMN2HTT
SCHEMBL11300977 0.79 TDP1 (0.46) NFE2L2KMT2AMEN1SMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10463647-B2 Erythropoietin expression promoter TOHOKU UNIVERSITY (JP) 2019-11-05 US disclosed
US-20180353475-A1 Erythropoietin Expression Promoter KAKE EDUCATIONAL INSTITUTION (JP) 2018-12-13 US disclosed
EP-2923700-B1 ERYTHROPOIETIN EXPRESSION PROMOTER UNIV TOHOKU (JP) 2018-11-07 EP disclosed
US-10004718-B2 Erythropoietin expression promoter TOHOKU UNIVERSITY (JP) 2018-06-26 US disclosed
CN-104936591-B Hematopoietin expression facilitator 国立大学法人东北大学 2018-05-29 CN disclosed
US-20150353489-A1 Erythropoietin Expression Promoter KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION KANAGAWA CHILDREN'S MEDICAL CENTER (JP) 2015-12-10 US disclosed
EP-2923700-A1 ERYTHROPOIETIN EXPRESSION PROMOTER Tohoku University (JP) 2015-09-30 EP disclosed
CN-104936591-A Erythropoietin expression promoter UNIV TOHOKU NAT UNIV CORP 2015-09-23 CN disclosed
CN-102532162-B 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMA CO LTD 2015-05-27 CN disclosed
EP-2570418-A2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-20 EP disclosed
EP-0444844-B1 New 15-dehydroxy-16-oxoprostaglandins R TECH UENO LTD (JP) 1995-01-18 EP disclosed
US-5346921-A Treatment of inflammation with 15-keto-prostaglandin compounds R-TECH UENO, LTD. (JP) 1994-09-13 US disclosed
US-5252605-A Promotion of wound-healing with 15-keto-prostaglandin compounds R-TECH UENO LTD. (JP) 1993-10-12 US disclosed
US-5221799-A New 15-dehydroxy-16-oxoprostaglandins K.K. UENO SEIYAKU OYO KENKYUJO (JP) 1993-06-22 US disclosed
US-5212324-A TREATMENT OF CATARACT WITH 15-KETO-PROSTAGLANDIN COMPOUNDS R.-TECH UENO LTD. (JP) 1993-05-18 US disclosed
EP-0503887-A2 Promotion of wound-healing with 15-keto-prostaglandin compounds R-TECH UENO LTD. (JP) 1992-09-16 EP disclosed
EP-0467564-A2 Treatment of inflammatory diseases with 15-keto-prostaglandin compounds R-TECH UENO LTD. (JP) 1992-01-22 EP disclosed
EP-0453127-A2 Treatment of cataract with 15-keto-prostaglandin compounds R-TECH UENO LTD. (JP) 1991-10-23 EP disclosed
EP-0444844-A2 New 15-dehydroxy-16-oxoprostaglandins R-TECH UENO LTD. (JP) 1991-09-04 EP disclosed
US-3971825-A (5,6) (10,11) BIS-METHYLENE, BRONCHODILATORS SANKYO COMPANY LIMITED (JA) 1976-07-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180353475-A1 Erythropoietin Expression Promoter EPOR, NFE2L2, FOXO1 NFE2L2 2/4885KMT2A 3254/4885MEN1 3086/4885
US-20150353489-A1 Erythropoietin Expression Promoter EPOR, NFE2L2, FOXO1 NFE2L2 2/4885KMT2A 3254/4885MEN1 3086/4885
US-10004718-B2 Erythropoietin expression promoter EPOR, NFE2L2, FOXO1 NFE2L2 2/4885KMT2A 3254/4885MEN1 3086/4885
US-10463647-B2 Erythropoietin expression promoter EPOR, NFE2L2, FOXO1 NFE2L2 2/4885KMT2A 3254/4885MEN1 3086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.