Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369141 | 0.83 | LMNA (0.50) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL286054 | 0.83 | LMNA (0.50) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL9420260 | 0.83 | NFE2L2 (0.55) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL29381894 | 0.81 | KMT2A (0.51) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL107259 | 0.81 | CSNK2A1 (0.59) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL30679777 | 0.81 | CSNK2A1 (0.59) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL96218 | 0.81 | KMT2A (0.51) | NFE2L2KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL501733 | 0.81 | MEN1 (0.55) | KMT2ASMN1; SMN2HTTMEN1CSNK2A1 | |
| SCHEMBL10952578 | 0.79 | ALDH1A1 (0.58) | NFE2L2KMT2ASMN1; SMN2HTTNPC1 | |
| SCHEMBL6915656 | 0.79 | CSNK2A1 (0.57) | NFE2L2KMT2ASMN1; SMN2HTTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345664-B2 | Process for the preparation of (S)-Netarsudil,its salts and polymorphs | Micro Labs Ltd. (IN) | 2022-05-31 | — | — | US | claimed |
| US-20210094918-A1 | PROCESS FOR THE PREPARATION OF (S)-NETARSUDIL,ITS SALTS AND POLYMORPHS | Micro Labs Ltd. (IN) | 2021-04-01 | — | — | US | claimed |
| WO-2021001713-A1 | PROCESS FOR THE PREPARATION OF (S)-NETARSUDIL, ITS SALTS & POLYMORPHS | MICRO LABS LIMITED (IN) | 2021-01-07 | — | — | WO | claimed |
| US-5574016-A | Peptide compound and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-12 | — | — | US | claimed |
| US-4416879-A | CEPHALOSPORINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-22 | — | — | US | claimed |
| CN-117957265-A | Process for producing dihydroxy compound and process for producing regenerated resin | 三菱瓦斯化学株式会社 | 2024-04-30 | — | — | CN | disclosed |
| CN-117916325-A | Thermoplastic resin composition, molded article, method for producing thermoplastic resin composition, and method for improving transmittance | 三菱瓦斯化学株式会社 | 2024-04-19 | — | — | CN | disclosed |
| US-20230295373-A1 | THERMOPLASTIC RESIN COMPOSITION FOR OPTICAL MATERIAL, MOLDED ARTICLE, COMPOUNDING AGENT, METHOD FOR PRODUCING THERMOPLASTIC RESIN COMPOSITION, AND METHOD FOR IMPROVING TRANSMISSIVITY | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2023-09-21 | — | — | US | disclosed |
| EP-4198092-A1 | THERMOPLASTIC RESIN COMPOSITION FOR OPTICAL MATERIAL, MOLDED ARTICLE, COMPOUNDING AGENT, METHOD FOR PRODUCING THERMOPLASTIC RESIN COMPOSITION, AND METHOD FOR IMPROVING TRANSMISSIVITY | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2023-06-21 | — | — | EP | disclosed |
| CN-116096779-A | Thermoplastic resin composition for optical material, molded article, compounding agent, method for producing thermoplastic resin composition, and method for improving transmittance | 三菱瓦斯化学株式会社 | 2023-05-09 | — | — | CN | disclosed |
| WO-2023068290-A1 | THERMOPLASTIC RESIN COMPOSITION, MOLDED ARTICLE, AND METHOD FOR PRODUCING AND METHOD FOR IMPROVING TRANSMITTANCE OF THERMOPLASTIC RESIN COMPOSITION | 三菱瓦斯化学株式会社 | 2023-04-27 | — | — | WO | disclosed |
| US-11345664-B2 | Process for the preparation of (S)-Netarsudil,its salts and polymorphs | Micro Labs Ltd. (IN) | 2022-05-31 | — | — | US | disclosed |
| US-5342935-A | Antagonists of immunosuppressive macrolides | MERCK & CO., INC. (US) | 1994-08-30 | — | — | US | disclosed |
| EP-0608198-A1 | Cyclic diphenylacetonenitriles as stabilisers | CIBA-GEIGY AG (CH) | 1994-07-27 | — | — | EP | disclosed |
| EP-0591102-A1 | 3-(2-Acyloxyethoxyphenyl)benzofuran-2-ones as stabilizers | CIBA-GEIGY AG (CH) | 1994-04-06 | — | — | EP | disclosed |
| EP-0589839-A1 | 3-(Dihydrobenzofuran-5-yl)benzofuran-2-ones as stabilizers | CIBA-GEIGY AG (CH) | 1994-03-30 | — | — | EP | disclosed |
| US-5190950-A | Antagonists of immunosuppressive macrolides | MERCK & CO., INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0463690-A1 | Antagonists of immunosuppressive macrolides | MERCK & CO. INC. (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094918-A1 | PROCESS FOR THE PREPARATION OF (S)-NETARSUDIL,ITS SALTS AND POLYMORPHS | VKORC1L1, CYP3A4, REN | NFE2L2 2259/4885KMT2A 3775/4885SMN1; SMN2 2773/4885 |
| US-11345664-B2 | Process for the preparation of (S)-Netarsudil,its salts and polymorphs | VKORC1L1, CYP3A4, REN | NFE2L2 2259/4885KMT2A 3775/4885SMN1; SMN2 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.