Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 8/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24177393 | 0.91 | HDAC6 (0.48) | HDAC6ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL20465965 | 0.91 | HDAC6 (0.48) | HDAC6ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL13201332 | 0.79 | APP (0.53) | HDAC6ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL18880097 | 0.73 | DYRK1A (0.54) | ESR1ESR2 | |
| SCHEMBL19217080 | 0.73 | ALOX5 (0.42) | HDAC6ESR1ESR2 | |
| SCHEMBL16720164 | 0.71 | HDAC6 (0.42) | HDAC6ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL2455968 | 0.70 | KCNH2 (0.47) | AHRCMA1TYRBRD4 | |
| SCHEMBL23555405 | 0.70 | ESR1 (0.44) | ESR1ESR2 | |
| SCHEMBL4428370 | 0.69 | GPR84 (0.45) | AHRCMA1TYR | |
| SCHEMBL20417352 | 0.68 | APP (0.41) | HDAC6HSD17B1HSD17B2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266493-B2 | Thioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES, INC. (US) | 2019-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266493-B2 | Thioacetate compounds, compositions and methods of use | TXN, TXN2, XDH | HDAC6 1428/4885ESR1 3725/4885ESR2 2636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.