Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20968229 | 0.85 | RAB9A (0.55) | NPC1LMNATP53GAAMAPK1 | |
| SCHEMBL20968167 | 0.82 | MAOA (0.47) | NPC1LMNATP53GAAMAPK1 | |
| SCHEMBL30850814 | 0.81 | HDAC6 (0.51) | NPC1LMNARAB9ASMN1; SMN2NR1H4 | |
| SCHEMBL20968217 | 0.80 | NPC1 (0.49) | NPC1LMNATP53GAAMAPK1 | |
| SCHEMBL3057263 | 0.80 | NR1H4 (0.61) | NPC1TP53RAB9ASMN1; SMN2PPARD | |
| SCHEMBL20968168 | 0.79 | S1PR1 (0.54) | NPC1LMNATP53GAAMAPK1 | |
| SCHEMBL3053264 | 0.78 | LMNA (0.60) | NPC1LMNATP53HTTRAB9A | |
| SCHEMBL20968173 | 0.78 | CASP3 (0.54) | NPC1LMNARAB9ASMN1; SMN2PPARD | |
| SCHEMBL5836424 | 0.77 | NR1H4 (0.66) | NPC1LMNATP53RAB9ASMN1; SMN2 | |
| SCHEMBL3068001 | 0.76 | MMP13 (0.49) | NPC1LMNATP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662164-B2 | Non-beta lactam antibiotics | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662164-B2 | Non-beta lactam antibiotics | OXA1L, O60361, CUTA | NPC1 2521/4885LMNA 1699/4885TP53 4798/4885 |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | OXA1L, O60361, CUTA | NPC1 2521/4885LMNA 1699/4885TP53 4798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.