Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 9/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19457710 | 0.86 | USP30 (0.50) | KMT2AMEN1CNR2CNR1 | |
| SCHEMBL20985107 | 0.84 | SMYD3 (0.40) | CNR2SMYD3CNR1 | |
| SCHEMBL19457895 | 0.79 | USP30 (0.44) | KMT2AMEN1CNR2CNR1 | |
| SCHEMBL16973743 | 0.75 | PRKAA2 (0.46) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL19457902 | 0.74 | HPGDS (0.42) | KMT2AMEN1SMYD3 | |
| SCHEMBL18987769 | 0.74 | HPGDS (0.50) | — | |
| SCHEMBL20872894 | 0.72 | KCNJ1 (0.53) | KMT2AMEN1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL19473757 | 0.72 | USP30 (0.46) | KMT2AMEN1 | |
| SCHEMBL19639844 | 0.71 | KCNJ1 (0.45) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL23731477 | 0.70 | HPGDS (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3231802-B1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-05-05 | — | — | EP | disclosed |
| US-10759788-B2 | Pharmaceutical uses of pyridine carboxamide derivatives | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-09-01 | — | — | US | disclosed |
| US-10442794-B2 | Processes for preparing pyridine carboxamide derivatives | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-10-15 | — | — | US | disclosed |
| US-20190152959-A1 | PROCESSES FOR PREPARING PYRIDINE CARBOXAMIDE DERIVATIVES | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-05-23 | — | — | US | disclosed |
| US-20190152958-A1 | PHARMACEUTICAL USES OF PYRIDINE CARBOXAMIDE DERIVATIVES | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152958-A1 | PHARMACEUTICAL USES OF PYRIDINE CARBOXAMIDE DERIVATIVES | CASK, PDXK, NADK | KMT2A 1897/4885MEN1 1604/4885PRKAA2 312/4885 |
| US-20190152959-A1 | PROCESSES FOR PREPARING PYRIDINE CARBOXAMIDE DERIVATIVES | CPS1, PDXK, SDHA | KMT2A 1137/4885MEN1 1352/4885PRKAA2 1687/4885 |
| US-10442794-B2 | Processes for preparing pyridine carboxamide derivatives | CPS1, PDXK, SDHA | KMT2A 1137/4885MEN1 1352/4885PRKAA2 1687/4885 |
| US-10759788-B2 | Pharmaceutical uses of pyridine carboxamide derivatives | CASK, PDXK, NADK | KMT2A 1897/4885MEN1 1604/4885PRKAA2 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.