SCHEMBL21001087

SCHEMBL21001087

CC(=O)OC1C(C)(C)CCCC12CC(C)=C(C)C2

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
MAPK1 P28482 1/20 0.33
KMT2A Q03164 1/20 0.33
PLA2G2A P14555 2/20 0.31
NLRP3 Q96P20 1/20 0.31
ATM Q13315 1/20 0.30
TSHR P16473 1/20 0.30
TRPM2 O94759 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30441197 1.00 CYP3A4 (0.33) CYP3A4MEN1LMNATP53MAPT
SCHEMBL25493699 0.84 CYP3A4 (0.33) CYP3A4MEN1LMNATP53MAPT
SCHEMBL14982984 0.80 CYP3A4 (0.37) CYP3A4MEN1LMNATP53MAPT
SCHEMBL21004855 0.79 CYP3A4 (0.34) CYP3A4MEN1LMNATP53MAPT
SCHEMBL21001023 0.78 CYP3A4 (0.33) CYP3A4
SCHEMBL21011970 0.78 CYP19A1 (0.33) CYP3A4PLA2G2ATRPM2
SCHEMBL21004857 0.75
SCHEMBL31418687 0.73 CYP3A4 (0.33) CYP3A4POLB
SCHEMBL21001034 0.73 CYP3A4 (0.33) CYP3A4POLB
SCHEMBL25493695 0.72 TRPA1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3713609-B1 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS FIRMENICH & CIE (CH) 2025-08-06 EP claimed
US-20250066690-A1 Spiro Compounds as Malodor Counteracting Ingredients FIRMENICH SA (CH) 2025-02-27 US claimed
CN-116763963-A Spiro compounds as malodor counteracting ingredients 弗门尼舍有限公司 2023-09-19 CN claimed
US-20230233425-A1 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR FIRMENICH SA (CH) 2023-07-27 US claimed
US-20230159853-A1 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS FIRMENICH SA (CH) 2023-05-25 US claimed
US-20200345601-A1 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR FIRMENICH SA (CH) 2020-11-05 US claimed
EP-3713610-A2 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR Firmenich SA (CH) 2020-09-30 EP claimed
EP-3713609-A2 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS Firmenich SA (CH) 2020-09-30 EP claimed
WO-2019101814-A2 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS FIRMENICH SA (CH) 2019-05-31 WO claimed
WO-2019101821-A2 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR FIRMENICH SA (CH) 2019-05-31 WO claimed
EP-4707270-A2 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS Firmenich SA (CH) 2026-03-11 EP disclosed
EP-4632382-A2 METHOD OF IDENTIFYING LAUNDRY MALODOR, MOLDY MALODOR AND/OR SWEAT MALODOR MODULATING COMPOUNDS Firmenich SA (CH) 2025-10-15 EP disclosed
EP-3713609-B1 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS FIRMENICH & CIE (CH) 2025-08-06 EP disclosed
US-20250066690-A1 Spiro Compounds as Malodor Counteracting Ingredients FIRMENICH SA (CH) 2025-02-27 US disclosed
US-12180434-B2 Spiro compounds as malodor counteracting ingredients FIRMENICH SA (CH) 2024-12-31 US disclosed
US-20200345601-A1 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR FIRMENICH SA (CH) 2020-11-05 US disclosed
EP-3713610-A2 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR Firmenich SA (CH) 2020-09-30 EP disclosed
EP-3713609-A2 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS Firmenich SA (CH) 2020-09-30 EP disclosed
WO-2019101821-A2 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR FIRMENICH SA (CH) 2019-05-31 WO disclosed
WO-2019101814-A2 SPIRO COMPOUNDS AS MALODOR COUNTERACTING INGREDIENTS FIRMENICH SA (CH) 2019-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066690-A1 Spiro Compounds as Malodor Counteracting Ingredients LPO, SORD, FOXO1 CYP3A4 144/4885MEN1 3102/4885LMNA 3412/4885
US-20200345601-A1 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR TAS2R8, TRPA1, TAS2R10 CYP3A4 145/4885MEN1 3715/4885LMNA 3892/4885
US-20230233425-A1 USE OF VOLATILE COMPOSITIONS TO LIMIT OR ELIMINATE THE PERCEPTION OF MALODOR TAS2R8, TRPA1, TAS2R10 CYP3A4 145/4885MEN1 3715/4885LMNA 3892/4885
US-12180434-B2 Spiro compounds as malodor counteracting ingredients LPO, SORD, FOXO1 CYP3A4 144/4885MEN1 3102/4885LMNA 3412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.