Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043049 | 0.86 | ALDH1A1 (0.42) | ALDH1A1HTTSMN1; SMN2P2RX7MEN1 | |
| SCHEMBL22001365 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22001366 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21042583 | 0.76 | SMN1; SMN2 (0.44) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21043124 | 0.74 | GRK2 (0.42) | ALDH1A1HTTSMN1; SMN2P2RX7PKM | |
| SCHEMBL21043082 | 0.72 | L3MBTL1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL22001368 | 0.70 | ALDH1A1 (0.66) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL19997527 | 0.68 | PDE10A (0.43) | P2RX7LMNA | |
| SCHEMBL22001173 | 0.66 | BRD4 (0.44) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22001748 | 0.65 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |