Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.32 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.32 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.32 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043060 | 0.86 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL22001365 | 0.80 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL22001748 | 0.80 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL22001367 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL22001173 | 0.75 | BRD4 (0.44) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL21043468 | 0.71 | CCR1 (0.31) | — | |
| SCHEMBL16593241 | 0.71 | CHRM1 (0.62) | — | |
| SCHEMBL22001368 | 0.70 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL22001366 | 0.67 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL19997527 | 0.65 | PDE10A (0.43) | LMNAP2RX7JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |