Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MFN2 | O95140 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334498 | 0.92 | ALDH1A1 (0.45) | HTTALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL12892262 | 0.83 | AVPR1A (0.45) | HTTALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL22404799 | 0.79 | AVPR1A (0.66) | HTTALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL11460990 | 0.78 | MEN1 (0.45) | HTTALDH1A1HSD17B10L3MBTL1AVPR1A | |
| SCHEMBL11537005 | 0.77 | HCAR1 (0.47) | HTTALDH1A1ALOX15HSD17B10AVPR1A | |
| SCHEMBL11538651 | 0.75 | GRM2 (0.37) | HTTALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL6406092 | 0.75 | MEN1 (0.46) | HTTALDH1A1CYP3A4CYP2C19MEN1 | |
| SCHEMBL13446998 | 0.73 | ALDH1A1 (0.31) | HTTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL1816886 | 0.70 | AVPR1A (0.49) | HTTALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL14557053 | 0.70 | NTRK1 (0.42) | MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240366540-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-11-07 | — | — | US | disclosed |
| EP-4444284-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | Albert Einstein College of Medicine (US) | 2024-10-16 | — | — | EP | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| WO-2023107880-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107880-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-06-15 | — | — | WO | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | HTT 403/4885ALDH1A1 4127/4885ALOX15 3106/4885 |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | HTT 403/4885ALDH1A1 4127/4885ALOX15 3106/4885 |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | HTT 403/4885ALDH1A1 4127/4885ALOX15 3106/4885 |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | HTT 403/4885ALDH1A1 4127/4885ALOX15 3106/4885 |
| US-20240366540-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | TFAM, MFN2, MAVS | HTT 3089/4885ALDH1A1 2950/4885ALOX15 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.