Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30751788 | 0.84 | PIK3CG (0.38) | PIK3CGLRRK2KDM4ERECQLDYRK1A | |
| SCHEMBL6719246 | 0.74 | PIK3CG (0.33) | PIK3CGLRRK2KDM4EDYRK1A | |
| SCHEMBL1109104 | 0.74 | KDM4E (0.39) | PIK3CGLRRK2KDM4EDYRK1A | |
| SCHEMBL12186825 | 0.74 | LRRK2 (0.47) | LRRK2KDM4EDYRK1A | |
| SCHEMBL13064505 | 0.71 | MAPK1 (0.41) | KDM4E | |
| SCHEMBL19006255 | 0.71 | ALDH1A1 (0.41) | LRRK2KDM4ETDP1 | |
| SCHEMBL13020443 | 0.71 | KDM4E (0.32) | PIK3CGLRRK2KDM4E | |
| SCHEMBL15691412 | 0.71 | RECQL (0.44) | KDM4ERECQL | |
| SCHEMBL15691392 | 0.69 | RECQL (0.33) | PIK3CGLRRK2RECQL | |
| SCHEMBL1721807 | 0.68 | PSMD14 (0.40) | PIK3CGKDM4ERECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720860-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2020-10-14 | — | — | EP | disclosed |
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| CN-111433212-A | Positive allosteric modulators of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2020-07-17 | — | — | CN | disclosed |
| WO-2019113179-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2019-06-13 | — | — | WO | disclosed |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | PIK3CG 306/4885LRRK2 743/4885KDM4E 862/4885 |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | PIK3CG 306/4885LRRK2 743/4885KDM4E 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.