Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048892 | 0.83 | PTGER1 (0.50) | MAPTPTGER1KEAP1NFE2L2APOBEC3A | |
| SCHEMBL29586104 | 0.75 | FAAH (0.55) | MAPTALDH1A1MEN1KMT2AFAAH | |
| SCHEMBL17258684 | 0.73 | KMT2A (0.55) | MAPTGLAALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL21048898 | 0.72 | KEAP1 (0.46) | MAPTMEN1KMT2ALMNAKEAP1 | |
| SCHEMBL15231555 | 0.71 | CYP2C9 (0.55) | MAPTMEN1KMT2AFAAHMGLL | |
| SCHEMBL17078809 | 0.71 | MEN1 (0.57) | MAPTALDH1A1MEN1KMT2AFAAH | |
| SCHEMBL30062604 | 0.71 | MEN1 (0.57) | MAPTALDH1A1MEN1KMT2AFAAH | |
| SCHEMBL17258969 | 0.71 | CYP19A1 (0.48) | KMT2AFAAHMGLL | |
| SCHEMBL21048953 | 0.71 | LMNA (0.53) | MAPTGLAMEN1KMT2ALMNA | |
| SCHEMBL21048810 | 0.70 | GAA (0.47) | ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |