SCHEMBL2105152

SCHEMBL2105152

N#Cc1ccc(C(=O)Nc2cccc(C(=O)Cl)c2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.60
MEN1 O00255 3/20 0.60
NPC1 O15118 2/20 0.60
RAB9A P51151 2/20 0.60
F2 P00734 1/20 0.57
PLG P00747 1/20 0.57
PLAU P00749 1/20 0.57
KLKB1 P03952 1/20 0.57
PRSS1 P07477 1/20 0.57
CYP11B1 P15538 1/20 0.57
CYP11B2 P19099 1/20 0.57
RXFP1 Q9HBX9 1/20 0.53
SIRT2 Q8IXJ6 1/20 0.53
KCNK3 O14649 1/20 0.53
KCNK9 Q9NPC2 1/20 0.53
ESR1 P03372 1/20 0.52
ALDH1A1 P00352 1/20 0.51
MAPT P10636 1/20 0.51
MLYCD O95822 1/20 0.51
TAS1R3 Q7RTX0 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2104597 0.89 BRAF (0.56) KMT2AMEN1F2PLGPLAU
SCHEMBL3610083 0.87 HPSE (0.67) KMT2AMEN1NPC1RAB9AF2
Hydrochloric Acid SCHEMBL2105154 0.86 HPSE (0.65) KMT2AMEN1NPC1RAB9AF2
SCHEMBL2832357 0.84 KMT2A (0.59) KMT2AMEN1NPC1RAB9AF2
SCHEMBL2838977 0.83 RAB9A (0.72) KMT2AMEN1NPC1RAB9AF2
SCHEMBL1359652 0.83 KCNK3 (0.76) KMT2AMEN1NPC1RAB9AKCNK3
SCHEMBL2012930 0.82 KCNK3 (0.67) KMT2AMEN1NPC1RAB9ACYP11B1
SCHEMBL13210705 0.82 NAMPT (0.66) KMT2AMEN1NPC1RAB9AF2
SCHEMBL259705 0.81 MEN1 (0.65) KMT2AMEN1NPC1RAB9AF2
SCHEMBL6788515 0.81 PTGS1 (0.63) KMT2AMEN1NPC1RAB9AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2023-11-23 US disclosed
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2023-09-19 US disclosed
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2021-07-29 US disclosed
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2021-05-04 US disclosed
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2019-10-08 US disclosed
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2018-05-17 US disclosed
US-9920026-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2018-03-20 US disclosed
EP-1714958-B9 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2017-05-31 EP disclosed
EP-1714958-B1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2016-12-21 EP disclosed
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2016-01-07 US disclosed
US-8563736-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2013-10-22 US disclosed
US-20120225891-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2012-09-06 US disclosed
US-8168825-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2012-05-01 US disclosed
US-8163804-B2 Composition for preventing harmful organisms MITSUI CHEMICALS, INC. (JP) 2012-04-24 US disclosed
US-20090192167-A1 Insecticidal and fungicidal composition MITSUI CHEMICALS, INC. (JP) 2009-07-30 US disclosed
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS MITSUI CHEMICALS, INC (JP) 2009-06-25 US disclosed
EP-1938685-A1 INSECTICIDAL AND BACTERICIDAL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-07-02 EP disclosed
EP-1913815-A1 PEST CONTROL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-04-23 EP disclosed
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide MITSUI CHEMICALS, INC. (JP) 2007-11-29 US disclosed
EP-1714958-A1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE Mitsui Chemicals, Inc. (JP) 2006-10-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide CYP1A1, CYP4B1, CYP2E1 KMT2A 1782/4885MEN1 3376/4885NPC1 656/4885
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 KMT2A 1782/4885MEN1 3376/4885NPC1 656/4885
US-20120225891-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 KMT2A 565/4885MEN1 2759/4885NPC1 1985/4885
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 KMT2A 1782/4885MEN1 3376/4885NPC1 656/4885
US-20090192167-A1 Insecticidal and fungicidal composition NOX3, PRDX1, CYP4X1 KMT2A 2083/4885MEN1 1780/4885NPC1 3199/4885
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 KMT2A 565/4885MEN1 2759/4885NPC1 1985/4885
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 KMT2A 565/4885MEN1 2759/4885NPC1 1985/4885
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 KMT2A 565/4885MEN1 2759/4885NPC1 1985/4885
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS PRDX3, CYP1A1, GSTA1 KMT2A 1594/4885MEN1 485/4885NPC1 2605/4885
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 KMT2A 565/4885MEN1 2759/4885NPC1 1985/4885
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 KMT2A 565/4885MEN1 2759/4885NPC1 1985/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.